In vivo induction of massive proliferation, directed migration, and
differentiation of neural cells in the adult mammalian brain
James Fallon, Steve Reid, Richard Kinyamu, Isaac Opole, Rebecca Opole,
Janie Baratta, Murray Korc, Tiffany L. Endo, Alexander Duong, Gemi Nguyen,
Masoud Karkehabadhi, Daniel Twardzik,
and Sandra Loughlin
...................................................................
this was a nice study in terms of documenting the cell growth,
following a ridge of cells and its growth pattern. Nice photos too.
here is a quote from the concluding paragraph of this article,
indicating possibilities for clinical use:
....................................................................
" Although other factors may
ultimately interact to produce optimal PMD under various
experimental and clinical conditions, it is surprising that application
of a single neurotrophic factor (TGFa) in an injured brain
region is sufficient to effect such significant repair mechanism(s)
with positive functional results. TGFa may have several mechanisms
of action, perhaps through interactions with multiple
TGFa-EGF receptor subtypes , which lead to behavioral
recovery, such as PMD of stem and progenitor cells, which
replace lost circuits and functions; induction of new phenotypic
expression in preexisting cells; and neuroprotection against
cytotoxic or apoptotic signals. TGFa may be an important
endogenous trophic factor in both central and peripheral tissues
throughout development, adulthood, and in response to injury
and degeneration of tissue. For example, an increase in TGFa
levels has been measured in the striata of some Parkinson’s
disease patients. Perhaps the TGFa released endogenously
in degenerative disorders is not at a high enough concentration
to offset the progressive neural loss with a compensatory
stimulation of PMD. Exogenously administered TGFa
over a threshold level in patients with Parkinson’s disease or
other chronic and acute neural damage may then lead to
system-specific regeneration and protection of neural circuitry,
as well as reversal of clinical symptoms."
........................................................................
Gail Vass wrote:
>
> Online edition of India's National Newspaper on indiaserver.com
> March 22, 2001
>
> Stem cells reverse damage
>
> STEM CELLS in the brain were able to repair damaged areas and restore
> function when stimulated by a growth- inducing protein, study by
> researchers at UC Irvine's College of Medicine has found.
>
<<<<<<<<<<<<<<<<< SNIP >>>>>>>>>>>>>>>>>>>>
> Judith Richards, London, Ontario, Canada
> [log in to unmask]
> Today’s Research...
> Tomorrow’s Cure
........................................................................
Thanks to Judith (and Gail)
Sorry to hear you are not feeling well Judith.
I have always admired your searching of the Cyber Ether
for encouraging research news about PD.
Someday we shall overcome.
.........................................................................
Ray Strand
Prairie Sky Design
-----------------( on the Edge of the Prairie Abyss )---------------
when the sky is clear
the ground is visible
49/dx PD 2 yrs/40? onset/retired
----------------------------------------------------------------------
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