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Hi John, My name is Pam Shapley, and I have been a lurker for about a year. I am writing because I am also in the Upjohn drug trial PNU-95666E. I am out of the blind phase and am in the open phase. I am taking the maximum amount alloweded. (48mg.) I am 50 years old and have been diagnosed with PD since January 1998. My symptoms are only on my right side. Loss of fine moter skills no arm swing, some tremor, limp, tired all the time. I was "lucky" I was diagnosed right away. That was due to in part the fact that I knew what I was looking at. My Aunt had Parkinson's for about 20 years. Some of you who have worked with Parkinson's Action Network and have seen the video "The Faces of Parkinson's" know who she is, my Aunt was Virginia Hayes. I have had fairly good results with Pnu-95666E. Very few if any side effects. It is the only drug I am taking at this time. During the blind phase I felt I was on the placebo up until the last two weeks of the 12 week period. I now believe I just needed to get up to the maximum level to see results. My Nuro feels that I could tolerate a higher dose and would see improved results, but the study only allows him to put me up to 48 mg. My symptoms are reduced, but not completly gone. When I went from the blind phase to the open phase I was slowl tapered off of the drug, then slowly incresed with the "real" drug. While I was off drug, my symptoms were bad. I will stay with this program as long as it last. My Nuro said as I progress I will need to add other medications since I am at the maximum. Best of Luck, Pam ----- Original Message ----- From: lamjam inc Sent: Tuesday, March 27, 2001 11:55 AM To: [log in to unmask] Subject: Upjohn drug trail PNU-95666E Hi all. I'm 46, diagnosed with PD in January, 2001, confirmed in February. I = started a Dopamine agonist drug trial (reference above) on February 26. = It runs twelve weeks. My symptoms are loss of fine motor control on my left side ( I am typing = this with one hand). I have a noticeable limp. I am tired all the = time. Folding socks is tough, etc. I have no tremors. I have = suspected Parkinson for 18 months (it took awhile and 3 GP's to get = diagnosed). Does anyone have experience with this drug trial? I am getting one of = five does levels (maybe placebo). I am trying to set my expectations = for symptom relief. How about similar symptom relief data with = Miraplex? Thanks. John A. Maurer ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn<br clear=all><hr>Get your FREE download of MSN Explorer at <a href="http://explorer.msn.com">http://explorer.msn.com</a><br></p> ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn