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Dear Mr. Gonzalez: If you will notice, all of your "dead zone" events are occurring about 3 hours after your last dose of Sinemet CR. Under those circumstances, the best interpretation of your problem is "end of dose effect" or "wearing off effect" There are several ways of dealing with this problem, and I would leave the choice up to your Neurologist. !) Increase each dose of Sinemet CR to 50/200 - this may make it last longer. 2) Increase the dose of Mirapex, or load the dosing more towards the morning hours. Mirapex may work better if you take a larger AM dose and dose it three times a day. 3) Use Comtan (Entacapone) to extend the duration of action of the Sinemet Which of these choices is best in your case depends on whether you have any side effects or other problems with the drugs. All of these alternatives seem to be based on a net increase in medication which may not be possible if you are already having side effects. Jorge Romero ----- Original Message ----- From: "Mario A. Gonzalez" <[log in to unmask]> To: <[log in to unmask]> Sent: Tuesday, March 20, 2001 2:55 PM Subject: Come on you guys - help me figure this out. I take a Sinemet Regular 25/100 at 6:30 - 10:30 - 2:30 - 6:30. I take a Sinemet CR 25/100 at 7:00 - 11:00 - 3:00 - 7:00 - 11:00. I take a Mirapex .75 at 7:00 - 1:00 and 7:00. at 10:00 - 2:00 and 6:00 I go into what I call the DEAD ZONE - totally wiped out - wasted - post op feeling. Based on what I read, the life span of Mirapex is about 8 hours. So, why does it only last 3 hours with me? AM I undermedicated? Sometimes I never catch up and stay like that until night time. Should I be having more MIRAPEX? or more Sinemet? Is this considered End of dose feeling? What do you think? Give it your best shot? Appreciate it, Mario [log in to unmask] ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn