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^^^^^^ WARM GREETINGS FROM ^^^^^^^^^^^^ :-) Ivan Suzman 51/39/36 [log in to unmask] :-) Portland, Maine land of lighthouses 34 deg. F :-) ******************************************************************** I imagine that many PWP's face the dilemma of having a prescription for Sinemet, but not really beieng sure about which combination of carbidopa andlevodopa is most desirable to use regularly. I have a few questions that I hope others may wish to answer or comment upon; 1) I am wondering if anyone on PIENO has experience with theblue 10/100, compared to the yello 25/100. 2) Frequently one sees reference to the supposed toxiciy of carbidopa if ingested at a rate of more than 75 mg per day. Without becoming unnecessarily worried, I do wonder if my total carbidopa intake per day, now at 14 pills x 25 mg per pill each day, or 350 mg of carbidopa per day, might do to me, Does anyone think it would be prudent to use the 10/100 formula of Sinemet? 3) Another question is about the tan, Sinemet CR50/200. Does this cause mid-dose, or peak-dose dyskinesia in anyone? 200 mg of L-dopa is quite a bit. I wonder if a pill dissolves slowly enough tolast for quite some time, or if it tends to hit hard all at once. 4) Like so many PWP's sleep can be invaluable, but elusive, and sometimes I fall into a cat-like pattern of sleep,/Would 50/200 CR at bedtime allow more sleep , by lasting longer than a similar 25/100 CR? The possibility of reducing my sleep debt is always of interest to me, and perhaps many others. 5) Finally, I find Sinemet rather harsh, and sometimes, actually uncomfortablY "ACTIVE" in my stomach. This is unpleasant, and even a little painful at times. Meanwhile, I find the slightly lighter, lemon-tinted, round, and I belive, Israeli-made 25/100,pill, so-called "generic" carbidopa-levodopa, quite digestible, more swallowable (no long pointed ends and smaller in size), and less bitter. it seems to be a bit milder and slightly shorter-lasting in its effect, despite having the equivalent milligrams of c-dopa and l-dopa to what isin each tablet of Sinemet.. Can anyone confirm or diagree with what I am noticing? I have no experience with Madopar, but would love to try it as I hear that it is gets dissolved much more quickly. I understandtha it takes about 20 miutes to be effective. Sinemet takes more like 40 minutes. That is a LOT of time to be stiffened up, or slowed down, while waiting for the pills to kick in. I could write volumes on this topic, but will stop here and hope for a good dialogue among us PWP's and caregivers, and physicians and nurses . Thank you. Ivan S. :-) (Smiling and very glad to be back on the List!) ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn