Hi Ivan S
I am 51, pd 17years, 25/100 14years, than pre. 2nd pallidotomy my
nurosurgeon ( DR Iacona Loma Linda htt://www.pallidotomy.com he is the best
in his feld).
took me off 25/100 and put me on 10/100, what a difference. my dyskinesia
all but disappeared, i felt much better. I can take more 10/100 to control
my PD with no side effects.
Yes I think 350mg. of Carbidopa is way to much. NO more than 70-100 mg. per.
day.
The CR 25/100 made me so dyskinetic I could not function. I got off them
real fast. Many can not tolerate CR I am told
Sleep is always a problem, I frequently get up in the middle of the night
take a 10/100 and sit in my hot tub until
I relax and can go back to sleep. Works for me.
This is only my experience on these matters.
I do know the Pallidotomy helped me very much, every thing from walking,
turning in bed, showring, getting dressed, jist feel better over all. If you
want to know more about my experience with my 2 Pallidotomy's contact me
direct if you want.
Hope this helps. Burdette Anderson
Boulder Mt.
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---Original Message-----
From: Ivan M Suzman <[log in to unmask]>
To: [log in to unmask] <[log in to unmask]>
Date: Wednesday, April 04, 2001 5:58 AM
Subject: Sinemet 10/100, 25/100, and 50/200 , and "generic"
carbidopa/levodopa
>^^^^^^ WARM GREETINGS FROM ^^^^^^^^^^^^ :-)
> Ivan Suzman 51/39/36 [log in to unmask] :-)
> Portland, Maine land of lighthouses 34 deg. F :-)
>********************************************************************
> I imagine that many PWP's face the dilemma of
>having a prescription for Sinemet, but not really
>beieng sure about which combination of carbidopa
>andlevodopa is most desirable to use regularly.
>
> I have a few questions that I hope others may wish
>to answer or comment upon;
>
>1) I am wondering if anyone on PIENO has experience
>with theblue 10/100, compared to the yello 25/100.
>
> 2) Frequently one sees reference to the supposed toxiciy of
>carbidopa if ingested at a rate of more than 75 mg per day.
>Without becoming unnecessarily worried, I do wonder
>if my total carbidopa intake per day, now at 14 pills x 25 mg
>per pill each day, or 350 mg of carbidopa per day, might do
>to me, Does anyone think it would be prudent to use the 10/100 formula of
>Sinemet?
>
>3) Another question is about the tan, Sinemet CR50/200. Does this cause
>
>mid-dose, or peak-dose dyskinesia in anyone? 200 mg of L-dopa is quite a
>bit. I
>wonder if a pill dissolves slowly enough tolast for quite some time, or
>if
>it tends to hit hard all at once.
>
>4) Like so many PWP's sleep can be invaluable, but elusive, and sometimes
>I fall into a cat-like pattern of sleep,/Would 50/200 CR at bedtime allow
>
>more sleep , by lasting longer than a similar 25/100 CR? The
>possibility of reducing my sleep
>debt is always of interest to me, and perhaps many others.
>
>5) Finally, I find Sinemet rather harsh, and sometimes, actually
>uncomfortablY "ACTIVE" in my stomach. This is unpleasant,
>and even a little painful at times. Meanwhile, I find the slightly
> lighter, lemon-tinted, round, and I belive, Israeli-made 25/100,pill,
>so-called "generic"
>carbidopa-levodopa, quite digestible, more swallowable (no long
>pointed ends and smaller in size), and less bitter. it seems to be
>a bit milder and slightly shorter-lasting in its effect, despite having
>the equivalent milligrams of c-dopa and l-dopa to what isin each tablet
>of Sinemet.. Can anyone confirm or diagree with what I am noticing?
>
>I have no experience with Madopar, but would love to try it
>as I hear that it is gets dissolved much more quickly. I
>understandtha it takes about 20 miutes to be effective. Sinemet
>takes more like 40 minutes. That is a LOT of time to be stiffened
>up, or slowed down, while waiting for the pills to kick in.
>
>I could write volumes on this topic, but will stop here and hope for
>a good dialogue among us PWP's and caregivers, and physicians
>and nurses .
>
>
>Thank you.
>Ivan S.
>:-) (Smiling and very glad to be back on the List!)
>
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