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We need to be careful about talking in absolute terms in regards to starting Sinemet. My neuro explained the rationale behind delaying it, but then told me that I was in my peak earning years and the Sinemet would be the most effective at relieving symptoms. He then gave me the option to start Sinement. Agonists have not been very effective for me while producing undesirable side effects even at low dosage. There is an individual in my support group with early onset that has used primarily Sinemet for over 14 years. You wouldn't know that he had PD if you saw him on the street. The point is that we are all different in the way that we react to the meds. PD is idiopathic which means that we have common symptoms, but not necessarily the same disease. Scientific studies are typically inconclusive and the idiopathic nature of the disease may be part of the reason. So the best each of us can do is get the facts and then work with our neuro to develop the best personalized treatment method. Phil Gesotti 51/Dx46 ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn