APOPTOSIS
PARAPTOIS
NECROSIS
???
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Nat Rev Mol Cell Biol 2000 Nov;1(2):120-9
Apoptosis in neurodegenerative disorders.
Mattson MP.
Laboratory of Neurosciences, National Institute on Aging, Gerontology Research
Center, 5,600 Nathan Shock Drive, Baltimore, Maryland 21224, USA.
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Neuronal death underlies the symptoms of many human neurological disorders,
including Alzheimer's, Parkinson's and Huntington's diseases, stroke, and
amyotrophic lateral sclerosis. The identification of specific genetic and
environmental factors responsible for these diseases has bolstered evidence for
a shared pathway of neuronal death--apoptosis--involving oxidative stress,
perturbed calcium homeostasis, mitochondrial dysfunction and activation of
cysteine proteases called caspases. These death cascades are counteracted by
survival signals, which suppress oxyradicals and stabilize calcium homeostasis
and mitochondrial function. With the identification of mechanisms that either
promote or prevent neuronal apoptosis come new approaches for preventing and
treating neurodegenerative disorders.
Publication Types:
Review
Review, academic
PMID: 11253364 [PubMed - indexed for MEDLINE]
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Ray Strand
Prairie Sky Design
-----------------( on the Edge of the Prairie Abyss )---------------
when the sky is clear
the ground is visible
49/dx PD 2 yrs/40? onset/retired
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