This makes sense. But I don't like it.
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Neurology 2001 Mar 27;56(6):730-6
Risk of dementia in Parkinson's disease: A community-based, prospective study.
Aarsland D, Andersen K, Larsen JP, Lolk A, Nielsen H, Kragh-Sorensen P.
Section of Geriatric Psychiatry (Dr. Aarsland), Rogaland Psychiatric Hospital,
and the Department of Neurology (Dr. Larsen), Central Hospital of Rogaland,
Stavanger, Norway.
OBJECTIVE: To calculate the incidence of and determine possible risk
factors for
dementia in PD. BACKGROUND: Dementia has important clinical consequences for
patients with PD and their caregivers, but the incidence is unknown.
METHODS: A
population-based cohort of nondemented patients with PD (n = 171) from the
county of Rogaland, Norway, was assessed at baseline and 4.2 years later
with a
comprehensive evaluation of motor, cognitive, and neuropsychiatric
symptoms. The
diagnosis of dementia was made according to the Diagnostic and Statistical
Manual of Mental Disorders, 3rd edition, revised (DSM-III-R) criteria,
based on
interview of the patient and a caregiver, cognitive rating scales, and
neuropsychologic tests. A representative sample of 3,062 nondemented elderly
subjects without PD served as control group. RESULTS: Forty-three patients with
PD were demented at follow-up evaluation, equivalent to an incidence rate of
95.3 per 1,000 person-years (95% CI, 68.2 to 122.0). The risk for the
development of dementia in patients with PD relative to the control subjects
after adjusting for age, sex, and education was 5.9 (95% CI, 3.9 to 9.1).
Predictive factors at baseline for dementia in PD in addition to age were Hoehn
& Yahr score >2 (OR, 3.4; 95% CI, 1.3 to 8.6) and Mini-Mental State Examination
score <29 (OR, 3.3; 95% CI, 1.3 to 8.2). CONCLUSIONS: Patients with PD have an
almost sixfold increased risk for becoming demented compared with subjects
without PD.
PMID: 11274306 [PubMed - indexed for MEDLINE]
.......................................................
Ray Strand
Prairie Sky Design
-----------------( on the Edge of the Prairie Abyss )---------------
when the sky is clear
the ground is visible
49/dx PD 2 yrs/40? onset/retired
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