Gene therapy is in the future.
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Curr Opin Mol Ther 2000 Oct;2(5):540-54
Gene therapeutic strategies for neurodegenerative diseases.
Baekelandt V, De Strooper B, Nuttin B, Debyser Z.
Laboratory for Experimental Neurosurgery and Neuroanatomy, CEHA Provisorium 1,
Minderbroedersstraat 17, B-3000 Leuven, Belgium.
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Gene transfer into the central nervous system by ex vivo or in vivo techniques
is a rapidly emerging field in neuroscience. Potential applications of gene
therapy for the nervous system include not only congenital single gene
disorders, but also brain tumors and acquired chronic diseases. Considerable
progress has been made in the understanding of neurodegenerative diseases such
as Parkinson's and Alzheimer's disease. As a result, gene therapy for
Parkinson's, and possibly Alzheimer's disease could be regarded as a realistic
alternative to the limited treatment options currently available. In this
review, we highlight the most important developments in gene transfer techniques
as well as the newest insights in the mechanisms of some neurodegenerative
disorders and put these into the perspective of gene therapeutic strategies for
the central nervous system.
PMID: 11249757 [PubMed - indexed for MEDLINE]
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Ray Strand
Prairie Sky Design
-----------------( on the Edge of the Prairie Abyss )---------------
when the sky is clear
the ground is visible
49/dx PD 2 yrs/40? onset/retired
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