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Dick: My experiences mirror yours in many ways. In my case, first left rotator cuff operation, then right rotator cuff problems while the left stubbornly refused to heal properly resulting in my refusing an operation on the right and living with the difficulty. Because both knees eventually needed arthoscopic surgery, the shoulder pains receded and the knees became the primary source of discomfort. I suppose if I would crack my skull open, the knees wouldn't hurt (poor joke). In any event, I take both Sinemet (a Levadopa formulation) and Requip, an agonist. I took Sinemet without Requip before taking them together. I also take Selegiline (Eldepryl, Depranyl?(sp)) and have taken it regularly throughout the various limb and joint pains. I can tell you without hesitation that The Parkinson drugs have had absolutely no effect on any condition or symptom other than those related to Parkinson's. If you can get on an agonist (Requip, Mirapex, Permax) for your PD, don't even think of Levadopa yet. This from a subscriber to the school of thought that believes that the best Levadopa is the Levadopa delayed in order t avoid its inevitable side effects. By the way, this thought is not universally held so others on the list may want to chip in. I tried both Vioxx and Celebrex for the pains but they didn't work either. Oh yes, if you are taking Selegiline (by any of its names), Keep in mind that Codeine, its derivatives and other forms of narcotic pain killer are contra indicated for any other drug which is considered to be an MAO-B inhibitor as is Selegiline. Good Luck and I'm sure the list members will augment my remarks. Paul H. Lauer ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn