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Having tried agonists unsuccessfully, I am now considering starting Sinemet. Can those of you taking Sinemet respond to these questions: What is the usual dose daily? My neuro. has me taking 25/100 (card/lev) 3 X a day, starting with 1/2 pill and working up to 300mg per day within 3 weeks. Do you feel well-being right away? Does the drug lessen tremor, or just improve rigidity and gait? Is it inevitable that you get on/off periods? dyskenesia? What are the side-effects and what would make you discontinue taking this drug? I realize how different everyone is and I expect the answers to these questions to be varied but any reaction to my concerns will be helpful. Many thanks!! Catherine ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn