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I was diagnosed in 1978.I was able to hold off for 2 years before I started sinemet. It made me so nauseated that by the time I got to work I headed straight to the ladies room to upchuck. I learned that drinking coffee with my sinemet stopped the nausea. It worked for me! Later on we were told pergolide ( permax) would be the greatest breakthrough ever. Well it was a wonderful breakthrough for me because that was about 1990 (as I recall) and the Sinemet after 10 years was not quite what it had been when I started in 1980. I am thankful we have sinemet!!I I hate to think what life would be without it-----looking for a cure next!! ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn