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J Neurol Sci 2001 Apr 1;185(2):129-34
A neuropathological study of the disturbance of the nigro-amygdaloid connections
in brains from patients with dementia with Lewy bodies.
Iseki E, Kato M, Marui W, Ueda K, Kosaka K.
Department of Psychiatry, Yokohama City University School of Medicine, 3-9
Fukuura, Kanazawa-ku, 236-0004, Yokohama, Japan
We neuropathologically and immunohistochemically investigated
characteristics of
the central amygdaloid nucleus lesion and its relationship with the substantia
nigra lesion in dementia with Lewy bodies (DLB) brains. Nine DLB, four
Parkinson's disease (PD) and four Alzheimer-type dementia (ATD) cases were
examined. The degree of neuronal loss in the substantia nigra was (+)-(+++) in
DLB cases, (+++) in PD cases and (+) in ATD cases. All DLB cases showed spongy
change and ubiquitin-positive spheroids in the central nucleus. The degree of
spongy change was (+)-(+++) in DLB cases, (+) in PD cases and (-)-(+) in ATD
cases, which was correlated with the degree of neuronal loss in the substantia
nigra in DLB cases. The number of ubiquitin-positive spheroids was parallel to
the degree of spongy change. The central nucleus receives dense dopaminergic
fibers from the substantia nigra. Many ubiquitin-positive spheroids were also
positive to alpha-synuclein and tyrosine-hydroxylase, suggesting that they
derive from the degeneration of terminal or distal axons of Lewy body-bearing
dopaminergic neurons in the substantia nigra. The disturbance of the
dopaminergic connections from the substantia nigra to the central nucleus
may be
responsible for psychotic symptoms in DLB patients.
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Ray Strand
Prairie Sky Design
-----------------( on the Edge of the Prairie Abyss )---------------
when the sky is clear
the ground is visible
49/dx PD 2 yrs/40? onset/retired
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