here is what happens to all those supplements you take
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J Nutr 2000 Sep;130(9):2343-8
Dietary coenzyme Q10 and vitamin E alter the status of these compounds in rat
tissues and mitochondria.
Ibrahim WH, Bhagavan HN, Chopra RK, Chow CK.
Department of Nutrition and Food Science, and Kentucky Agricultural Experiment
Station, University of Kentucky, Lexington, KY 40506, USA.
Vitamin E (VE) and coenzyme Q (CQ) are essential for maintaining functions and
integrity of mitochondria, and high concentrations of these compounds are found
in their inner membranes. This study was conducted to examine the interaction
between exogenously administered CQ10 and VE in rats. Male Sprague-Dawley rats
(12 mo old) were fed a basal diet (10 IU VE or 6.7 mg RRR-alpha-tocopherol
equivalent) supplemented with either 0 or 500 mg CQ10, and 0, 100 or 1310 IU
VE/kg diet for 14 or 28 d. Liver, spleen, heart, kidney, skeletal muscle, brain
and serum were analyzed for the levels of CQ10, CQ9 and VE. CQ10 supplementation
significantly (P: < 0.05) increased CQ10 concentration in the liver and spleen
(total and mitochondria) and serum, but not in other organs. Interestingly, rats
supplemented with CQ10 plus 100 IU VE/kg diet had significantly higher CQ10
levels in the liver and spleen, whereas those supplemented with CQ10 plus 1310
IU VE/kg diet had lower levels, compared with those supplemented with CQ10
alone. As expected, dietary VE increased VE content in all of the organs
analyzed in a dose-dependent manner. However, rats fed the basal diet
supplemented with CQ10 had significantly higher VE levels in liver (total and
mitochondria) than those not receiving CQ10 supplementation. CQ9 levels were
higher in the liver and spleen, lower in skeletal muscle and unaltered in brain,
serum, heart and kidney of rats supplemented with CQ10 compared with the
controls. These data provide direct evidence for an interactive effect between
exogenously administered VE and CQ10 in terms of tissue uptake and retention,
and for a sparing effect of CQ10 on VE. Data also suggest that dietary VE plays
a key role in determining tissue retention of exogenous CQ10.
PMID: 10958833 [PubMed - indexed for MEDLINE]
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Ray Strand
Prairie Sky Design
-----------------( on the Edge of the Prairie Abyss )---------------
when the sky is clear
the ground is visible
49/dx PD 2 yrs/40? onset/retired
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