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Ann N Y Acad Sci 2000;920:28-32
Genetics of Parkinson's disease.
Polymeropoulos MH.
Novartis Pharmaceuticals Corporation, Pharmacogenetics Department, 9 West
Watkins, Gaithersburg, MD 20878, USA. [log in to unmask]
Several genetic factors have been recently recognized as related to the etiology
of Parkinson's disease. Mutations in the genes coding for alpha-synuclein and
ubiquitin carboxy-terminal hydrolase have been identified in families with
autosomal dominant Parkinson's disease. Mutations in the Parkin gene are
responsible for autosomal recessive parkinsonism. These first pieces of the
molecular puzzle of Parkinson's disease offer novel insights into the
pathophysiology of the illness.
Publication Types:
Review
Review, tutorial
PMID: 11193165 [PubMed - indexed for MEDLINE]
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Ray Strand
Prairie Sky Design
-----------------( on the Edge of the Prairie Abyss )---------------
when the sky is clear
the ground is visible
49/dx PD 2 yrs/40? onset/retired
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