check out this news item
what is interesting is the nigrostriatal connection (pun unintended)
someone is looking at nigrostriatal neurons
the abstract is not yet available at Pub Med
.......................................................
AXONAL REGENERATION IN RAT BRAIN MAY PAVE WAY FOR PARTIAL REPAIR OF
SPINAL CORD INJURY
Treatment of rats with chondroitinase ABC following experimental
division of central nervous system (CNS) axons facilitates axonal
regrowth to their proper targets, according to a report in the May issue
of Nature Neuroscience.
http://molecularmedicine.medscape.com/36566.rhtml?srcmp=mm-042701
.......................................................
>
> Dr. Fawcett and his colleagues measured CNS axonal regeneration after nigrostriatal tract axotomy in
> untreated rats and rats that received repeated infusions of chondroitinase ABC to the injury site.
>
> Dopaminergic axons grew through the injury site of treated rats along the course of the original nigrostriatal
> tract and back to their original targets, the authors report. In untreated rats, however, axons failed to
> regenerate beyond the axotomy site.
>
> Immunohistochemistry results confirmed the long-distance regeneration of cut dopaminergic nigral axons in
> animals treated with chondroitinase ABC, but not in untreated animals. Additional studies demonstrated that
> chondroitinase ABC (but not penicillinase, a control protein) degraded chondroitin sulfate in the region
> where axonal regeneration was proceeding.
.......................................................
Ray Strand
Prairie Sky Design
-----------------( on the Edge of the Prairie Abyss )---------------
when the sky is clear
the ground is visible
49/dx PD 2 yrs/40? onset
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