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Maryse, Comtan is a COMT inhibitor, the enzyme that breaks down dopamine. Per their website" "COMTAN is a selective and reversible inhibitor of catechol O-methyltransferase (COMT) that extends the elimination half-life of levodopa (t1/2) and alters the pharmacokinetics of levodopa." http://www.comtan.com/content/dr_ComtanProductOverview.htm Your data may be addressing the cause of side effects or why it is more effective. Phil Gesotti ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn