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Phil, thank you for the URL about Comtan. As is shown in the following excerpt, it inhibits peripheral COMT metabolism, mainly in the digestive tube, liver and plasma. seems to work well for a lot of people. Maryse "Entacapone (COMTAN) inhibits peripheral catechol O-methyltransferase (COMT) metabolism of levodopa, increasing and smoothing the central bioavailability of levodopa. Entacapone thus provides more constant dopaminergic stimulation that has been shown to result in improved control of levodopa-associated motor fluctuations.3" ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn