this abstract combines my two big interests--
PD and Geodesic Domes
go figure
still exploring effect of anti-oxidants on progression
don't forget to take your E, C, grape seed extract and etc...
won't hurt, might help?
saw a recent abstract that claimed apoptotic pathway not oxidative
a few things need to be sorted out
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Parkinsonism Relat. Disord. 2001 Jul;7(3):243-246
Fullerene-based antioxidants and neurodegenerative disorders.
Dugan LL, Lovett EG, Quick KL, Lotharius J, Lin TT, O'Malley KL.
Department of Neurology and Center for the Study of Nervous System Disease,
Washington University School of Medicine, 63110, St. Louis, MO, USA
Water-soluble derivatives of buckminsterfullerene (C(60)) derivatives are a
unique class of compounds with potent antioxidant properties. Studies on
one class of these compounds, the malonic acid C(60) derivatives
(carboxyfullerenes), indicated that they are capable of eliminating both
superoxide anion and H(2)O(2), and were effective inhibitors of lipid
peroxidation, as well. Carboxyfullerenes demonstrated robust
neuroprotection against excitotoxic, apoptotic and metabolic insults in
cortical cell cultures. They were also capable of rescuing mesencephalic
dopaminergic neurons from both MPP(+) and 6-hydroxydopamine-induced
degeneration. Although there is limited in vivo data on these compounds to
date, we have previously reported that systemic administration of the C(3)
carboxyfullerene isomer delayed motor deterioration and death in a mouse
model of familial amyotrophic lateral sclerosis (FALS). Ongoing studies in
other animal models of CNS disease states suggest that these novel
antioxidants are potential neuroprotective agents for other
neurodegenerative disorders, including Parkinson's disease.
PMID: 11331193 [PubMed - as supplied by publisher]
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Ray Strand
Prairie Sky Design
-----------------( on the Edge of the Prairie Abyss )---------------
when the sky is clear
the ground is visible
49/dx PD 2 yrs/40? onset
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