Apomorphine
Apomorphine is also a D1 and D2 agonist, but since it is given
parentally via subcutaneous injection, its use is generally witheld
until problems with motor fluctuations and 'on-off' fluctuations
occur which are not being easily controlled via other drugs.
As a result of this, initiation of therapy is best instituted in the
context of a specialist Parkinson's clinic.
Side effects:
nausea or vomiting.-on account of this, the patient needs to be
given Domperidone as an anti-emetic prior to the use of Apomorphine.
http://medweb.bham.ac.uk/http/depts/clin_neuro/teaching/tutorials/parkinsons/parkinsons1.html
Hi, Mario, Bob,...
I was dignosed PD in 1980.(At 30) Now, I'm suffer -daily- three or four severe ON-OFF episodes. I use
the Clorhidrate of Apomorphine Britaject self injectable Pen just as a RESCUE to bridge the OFF times
ONLY if I'm out of home or in such a set of circumstances I can not wait until next ON comes.
2ml/mg injection is enough to push me -in 5-8 minutes to- an excellent quality ON lasting 50
minutes when it finishes abruptely.
I've made it so for years -without domperidone or any other similar drug-
Antonio Cortina, Barcelona, Spain
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