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E-MOVE reports from the 53rd Annual Meeting of the American Academy of Neurology in Philadelphia May 5-11, 2001. Poster and Platform session numbers refer to abstracts published in Neurology 2001;56 (Supplement 3). 1. P04.102 Stereotaxic implantation of retinal pigment epithelial cells attached to microcarriers in advanced Parkinson disease (PD) patients: A pilot study RL Watts, CD Raiser, NP Stover, ML Cornfeldt, AW Schweikert, T Subramanian, RAE Bakay Implantation of dopamine-producing retinal cells into the striatum can improve parkinsonian symptoms, according to this report. Six patients with advanced PD (mean disease duration 10.2 years) were implanted with human retinal pigment epithelial cells attached to microscopic cross- linked gelatin spheres (Spheramine) without immunosuppression. Each patient received approximately 325000 cells, placed in 5 tracts 5 mm apart on the side contralateral to the worst symptoms. UPDRS motor off scores fell for each patient, with an average of 17 points reduction after 3 months. Dyskinesia Rating scores improved 60% in the same period. One patient has been followed for a year, and two others for 6 months, with maintenance of improvements in motor score and dyskinesia. Supported by Titan Pharmaceuticals 2. S46.001 Intraventricular administration of GDNF in the treatment of Parkinson's disease JG Nutt, JM Bronstein, JH Carter, et al. Fifty patients received placebo or 25-4000 micrograms intraventricular glial cell line-derived neurotrophic factor monthly for 8 months. No improvements were seen in on or off UPDRS motor scores, despite clear evidence of biological effects of treatment, including anorexia, weight loss, and sensory symptoms in most treated patients. In 1 patient who died of unrelated causes, there was no evidence of increased tyrosine hydroxylase-positive fibers in the striatum. Supported by Amgen and Medtronic Copyright 2000 WE MOVE http://www.wemove.org janet paterson: an akinetic rigid subtype, albeit perky, parky . pd: 54/41/37 cd: 54/44/43 tel: 613 256 8340 email: [log in to unmask] . a new voice: the nnnewsletter: http://groups.yahoo.com/group/janet313/ . a new voice: the bbbook: http://www.geocities.com/janet313/wordbook/ . a new voice: the wwweb site: http://www.geocities.com/janet313/ . ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn