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Hello all,

In an article posted on the PARKINSN on-line web news pages
titled "Bresagen Limited Clones Australia's First Pig" this
statement caught my eye: "BresaGen recently demonstrated an
ability to control the differentiation of embryonic stem cells to
essentially pure cultures of dopamine producing cells."

I e-mailed BresaGen for further details and received the following
reply from Richard Stewart, Project Manager, Cell Therapy
Program.

"Thanks for your recent enquiry regarding dopaminergic stem cells.
Bresagen researchers have shown that they can control the
differentiation of mouse embryonic stem cells into essentially pure
dopamine-producing neurons. We are currently testing whether we
can reproduce these results using human embryonic stem cells.

"Although these results are extremely encouraging, unfortunately
there is still a lot of research that needs to be done before we can
produce a limitless supply of human dopamine-producing neurons
that are suitable for human therapies for treating Parkinson's
Disease. We estimate that early stage human clinical trials may
commence within the next 5-7 years, keeping in mind that the
estimate .... is only a best case scenario estimate and many
circumstances beyond our control can significantly delay our road
to the clinic."

I imagine this effort would take less time if there were federal
funding for embryonic stem cell research.

Incidentally, no one has yet reported being able to develop
dopamine-producing neurons from adult stem cells.

According to
http://www.savannahmorningnews.com/smn/stories/011601/
LOCstemcell.shtml, Tuesday, January 16, 2001, BresaGen has
moved its stem cell project to Athens GA.

Phil Tompkins

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