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>From: WE MOVE <[log in to unmask]> >To: <[log in to unmask]> >Subject: Prevalence and Treatment of Excess Daytime Sleepiness in PD (AAN 2001) >Date: Wed, 23 May 2001 16:23:51 -0500 > >E-MOVE reports from the 53rd Annual Meeting of the American Academy of >Neurology in Philadelphia May 5-11, 2001. Poster and Platform session >numbers refer to abstracts published in Neurology 2001;56 (Supplement 3). > >1. S40.001 Excessive daytime sleepiness and sudden onset sleep in >Parkinson's disease: A survey from 18 Canadian movement disorders clinics >AE Lang, DE Hobson, W Martin, J Rivest > >Excess daytime sleepiness is very common in PD, and the Epworth Sleepiness >Scale is a poor predictor of sudden onset of sleep, according to this >report. Six hundred thirty-eight consecutive non-demented PD patients, >including 420 drivers, were assessed for excess daytime sleepiness (EDS, >defined as ESS score of 7 or greater) and sudden onset of sleep (SOS), >using a modified Epworth Sleepiness Scale with specific inquiries about >SOS during driving, talking, working, or doing chores. EDS was present in >55% of drivers. Sixteen patients (4%) reported falling asleep at the >wheel, only 3 of whom did not experience warning signs. These 16 patients >had a mean ESS of 10.8, versus 6.8 for other patients. However, neither >the modified ESS nor specific questions extracted from it had a >sensitivity of more than 50% for prediction of falling asleep at the >wheel. Treatment with dopamine agonists plus levodopa was more likely to >cause EDS than treatment with levodopa alone. > >Supported by Boehringer-Ingelheim > > >2. P03.140 "Sleep attacks" and excessive daytime sleepiness (EDS) in >Parkinson disease: A survey of 200 consecutive patients >NP Stover, MS Okun, RL Watts > >Two hundred consecutive PD patients were interviewed regarding presence of >"sleep attacks", defined as sudden onset of sleep without feeling sleepy >at all. Twenty-nine patients (14%) reported sleep attacks, of whom 28 had >EDS as measured by the Epworth Sleepiness Scale. None had fallen asleep >while driving. Sleep attacks occurred with all dopaminergic agents. > > >3. S40.003 Modafinil for the treatment of excessive daytime sleepiness in >patients with Parkinson's disease >CH Adler, JN Caviness, JG Hentz, M Lind, J Tiede > >Modafinil is an effective treatment for EDS, according to this report. >Twenty-one patients with ESS score of 10 or greater received placebo or >modafinil 200 mg/day for 3 weeks, followed by crossover to the other >treatment arm. The modafinil-first group showed a significant carryover >effect, and was therefore not included in the final analysis of results. >ESS scores in treated patients fell from 17.8 to 14.4, versus 16.0 to 17.0 >for placebo (p=0.039). No significant changes were seen in UPDRS I or III >scores, or percent on time as reported by patient diaries. The authors >note that the baseline EDS scores are similar to those in patients with >narcolepsy. > >Supported by Cephalon > >Copyright 2000 WE MOVE >http://www.wemove.org janet paterson: an akinetic rigid subtype, albeit perky, parky . pd: 54/41/37 cd: 54/44/43 tel: 613 256 8340 email: [log in to unmask] . a new voice: the nnnewsletter: http://groups.yahoo.com/group/janet313/ . a new voice: the wwweb site: http://www.geocities.com/janet313/ . a new voice: the jjjournal: http://www.geocities.com/janet313/ . ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn