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>From: WE MOVE <[log in to unmask]> >To: <[log in to unmask]> >Subject: DBS Targeting (AAN 2001) >Date: Tue, 22 May 2001 13:45:46 -0500 > >E-MOVE reports from the 53rd Annual Meeting of the American Academy of >Neurology in Philadelphia May 5-11, 2001. Poster and Platform session >numbers refer to abstracts published in Neurology 2001;56 (Supplement 3). > >P04.091 Superior outcomes of bilateral STN DBS in IPD attributed to >precise intraoperative localization techniques >HM Bronte-Stewart, BC Hill, K McGuire, AY Minn, TA Courtney, G Heit > >Precise targeting of DBS electrodes in the subthalamic nucleus can give >motor improvements of 80% without adverse effects, according to this >report. > >Fifteen patients with PD received DBS to the STN using an iterative >electrode localization protocol combining MRI, ventriculography, and >microelectrode recording, to ensure the electrode was located in the >center of the sensorimotor area. Final location was determined within 300 >micrometers, with repositioning for deviations of approximately one >millimeter. The authors note that such a shift was enough to change the >immediate quantitative outcome intraoperatively. At six months, UPDRS off >motor score was 80% improved (range 68-89%) compared to baseline, and "no >adverse effects occurred." > >The authors conclude, "Our clinical outcomes from bilateral STN DBS are >above those reported so far. We believe that the excellent outcomes are >partially due to the knowledge and therefore correction of unavoidable >‘drift' in the final DBS electrode location from that planned. The drift >is probably due to the non-tensile properties of the electrode and >heterogeneities in brain tissue turgor." >http://www.wemove.org janet paterson: an akinetic rigid subtype, albeit perky, parky . pd: 54/41/37 cd: 54/44/43 tel: 613 256 8340 email: [log in to unmask] . a new voice: the nnnewsletter: http://groups.yahoo.com/group/janet313/ . a new voice: the wwweb site: http://www.geocities.com/janet313/ . a new voice: the jjjournal: http://www.geocities.com/janet313/ . ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn