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Dear Paul, I asked the question about contraindications with lithium --against either Selegiline or any of the Agonists (Permax, Mirapex, Requip --of the pharmacist who is our Honorary Professional Advisor to the Parkinson's Association of WA. Below is his reply. I (Joy) would be asking how long a person has been on lithium too, since I seem to recall it is one of the drugs which can give PD like symptoms if taken over a long period. IMHO, I agree with Andrew, there are much better drugs available to treat depression, although I know that some people with bi-polar disorder manage to do well on lithium. But then there is a big difference between bi-polar disorder and the depression of PD. (Isn't there?) Anyway, here (at last) is what Andrew said: Joy Graham ................ Dear Joy, There is no theoretical interaction between lithium and these drugs. Of course, I would worry when the lithium was started - did the person have mood disorder before the advent of PD or vice versa? As you know, PD does funny things to lots of different chemicals in the brain. Levodopa and the dopamine agonists usually have a positive effect on mood. If someone develops depression after diagnosis then we traditionally rely on antidepressants (SSRIs) now such as fluoxetine, paroxetine, and the most preferred in my book - sertraline. Psychotic episodes, hallucinations and vivid dreams suggest over-treatment. Lithium is such a nasty drug with some pretty serious side effects. I wouldn't take it! Hope these comments are useful. Andrew. Andrew J James Chief Pharmacist Department of Pharmacy Royal Perth Hospital GPO Box X2213 Perth 6847 Western Australia Tel: 61 8 9224 2478 Fax: 61 8 9224 2939 E-mail: [log in to unmask] -----Original Message----- From: [log in to unmask] [mailto:[log in to unmask]] Sent: Tuesday, 5 June 2001 10:08 To: [log in to unmask] Subject: Re: Contraindications Dear Andrew, The question (below) has been asked on the PD List: I know there are some reservations about its use with Levodopa. Can you let us know please? Many thanks JOY Graham .............................. >Does anyone know if Lithium (taken for mood disorder) is contraindicated >>against either Selegiline or any of the Agonists (Permax, Mirapex, Requip). >>I'll appreciate all replies but would particularly appreciate hearing from >>the medical and related fields people on the list. > >X-From_: [log in to unmask] Tue Jun 5 04:50:56 2001 >X-Sender: cmeyer2@mail >Date: Mon, 4 Jun 2001 15:47:16 -0500 >Reply-To: "Parkinson's Information Exchange Network" ><[log in to unmask]> >Sender: "Parkinson's Information Exchange Network" ><[log in to unmask]> >From: "Charles T. Meyer, M.D." <[log in to unmask]> >Subject: Re: Contraindications >To: [log in to unmask] > >Hi Paul, > >While I haven't researched the matter I have never heard or read of any >drugs or PD and drugs like Lithium .You should check with your doctor >though and remember that drugs can interact with each or alone in strange >ways in PWP's, > >Charlie. > >Charles T. Meyer, M.D. >Middleton, WI >PD DX 12 years (at age 44) >Age 56 > >---------------------------------------------------------------------- >To sign-off Parkinsn send a message to: mailto:[log in to unmask] >In the body of the message put: signoff parkinsn > >Hi Paul, > >While I haven't researched the matter I have never heard or read of any >drugs or PD and drugs like Lithium .You should check with your doctor >though and remember that drugs can interact with each or alone in strange >ways in PWP's, > >Charlie. > > > > >At 09:51 PM 6/3/01 -0400, you wrote: >>Does anyone know if Lithium (taken for mood disorder) is contraindicated >>against either Selegiline or any of the Agonists (Permax, Mirapex, Requip). >>I'll appreciate all replies but would particularly appreciate hearing from >>the medical and related fields people on the list. >> >>Paul H. Lauer >> >>---------------------------------------------------------------------- >>To sign-off Parkinsn send a message to: mailto:[log in to unmask] >>In the body of the message put: signoff parkinsn > >Charles T. Meyer, M.D. >Middleton, WI >PD DX 12 years (at age 44) >Age 56 > >---------------------------------------------------------------------- >To sign-off Parkinsn send a message to: mailto:[log in to unmask] >In the body of the message put: signoff parkinsn ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn