Congratulations:
This drug may be a neuro-preservative.
Lots of luck.
I do not have experience with the drug.
Since it is in clinical trials, few would have experience.
Ray
........................................................
J Neural Transm Suppl 2000;(60):171-86
Neurotoxins induce apoptosis in dopamine neurons: protection by
N-propargylamine-1(R)- and (S)-aminoindan, rasagiline and TV1022.
Maruyama W, Akao Y, Youdim MB, Naoi M.
Department of Basic Gerontology, National Institute for Longevity Sciences, Obu,
Aichi, Japan.
In Parkinson's disease, apoptosis was proposed to cause cell death in nigral
dopamine neurons. An endogenous dopaminergic neurotoxin, N-methyl(R)salsolinol,
stereo-selectively induced apoptosis in human neuroblastoma SH-SY5Y cells. In
this paper the intracellular mechanism of apoptosis was studied using
N-methyl(R)salsolinol, 6-hydroxydopamine and peroxynitrite as inducers of
apoptosis. Apoptotic cascade was initiated by opening of mitochondrial
permeability transition pore, as shown by collapse of mitochondrial membrane
potential, deltapsim. Apoptosis was executed by caspase 3 activation, followed
by DNA fragmentation, which was antagonized by overexpressed Bcl-2.
Propargylamines were found to protect the cells from apoptosis, and rasagiline,
a selective irreversible inhibitor of type B monoamine oxidase was the most
potent to prevent the cell death. Rasagiline preserved deltapsim, which was
proved also in isolated mitochondria, and rasagiline completely suppressed the
activation of caspases and DNA fragmentation. These results suggest that
mitochondria regulate apoptotic process, which may be a target of
neuroprotection by rasagiline.
PMID: 11205138 [PubMed - indexed for MEDLINE]
........................................................
Rees Jenkins wrote:
>
> My neuro is recommending me for a Phase 3 clinical trial for rasageline.
> Anybody have any experience with it?
>
> Rees Jenkins
>
..........................................................
Ray Strand
Prairie Sky Design
-----------------( on the Edge of the Prairie Abyss )---------------
when the sky is clear
the ground is visible
49/dx 47/40? onset
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