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Sun Herald Biloxi Science, religion at odds over stem cell research By PAUL RECER THE ASSOCIATED PRESS WASHINGTON - Many scientists believe stem cells hold the promise of dramatic new treatments for disease, offering hope to millions of patients. But some groups oppose using stem cells taken from embryos because this results in the embryo's death. Instead, they favor research limited to stem cells taken from mature tissue. President Bush has ordered federal funding of embryonic stem cell research delayed while the policy is reviewed. A decision by the administration is expected this month. Here are some questions and answers on this issue: QWhat are stem cells? AStem cells are the fundamental building blocks for all the tissues in the body. They can develop into bone, brain, muscle, skin and all the other organs. QWhat kinds of stem cells are there? AThere are three types: totipotent, pluripotent and multipotent, each representing a different stage in development. QWhat are totipotent stem cells? ATotipotent stem cells form when a fertilized egg first divides. Totipotent stem cells can develop into a complete individual. QWhat are pluripotent stem cells? AAfter a few days, totipotent stem cells form a blastocyst, a ball of cells. The inner layer contains pluripotent stem cells, which are capable of developing into any tissue in the body. Pluripotent stem cells, however, cannot become a complete individual. Pluripotent stem cells also are called embryonic stem cells. QWhat are multipotent stem cells? AMultipotent stem cells are found in mature tissue and are formed by the body to replace worn-out cells in tissues and organs. Stem cells from the bone marrow, for instance, form the various kinds of blood cells. Neural stem cells can form nerve and brain cells. Multipotent stem cells are sometimes called somatic or adult stem cells. QHow are stem cells useful in medicine? AResearchers believe that stem cells have great promise in the treatment of many illnesses, from brain disease to diabetes to heart failure. Experts believe they can learn to direct the development of stem cells into various types of new cells that can rejuvenate or even replace ailing organs. For instance, some believe it may be possible to grow insulin-producing cells to cure some forms of diabetes, or nerve cells to restore function for patients paralyzed by spinal injury. QWhich type of stem cell is best? AThat is not known. Some researchers believe embryonic stem cells are best because they are the most versatile. Also, embryonic stem cells can grow vigorously, forming colonies that will expand virtually forever. But research has shown that adult stem cells also are capable of forming many types of cells. For instance, some mouse experiments have shown that neural stem cells from the brain can be coaxed into growing muscle, liver and heart cells. Adult stem cells, though, are more difficult to grow and do not survive in the lab as long as embryonic stem cells. Many researchers believe that both embryonic and adult stem cells should be studied because it is unclear now which will ultimately be the most useful in medicine. QWhy is embryonic stem cell research controversial? AAn embryo is killed when the pluripotent stem cells are extracted. Many people are ethically opposed to killing human embryos for any purpose. A 1995 law forbids federal funding of research in which a human embryo would be destroyed, injured or placed at risk. QDoes that mean federal money cannot be used for embryonic stem cell research? ANot necessarily. In 1999, the National Institutes of Health established regulations that would permit federal funding provided the embryonic stem cells were harvested by privately funded laboratories. Federal money would be used to study the stem cells, but not to harm the embryos from which cells were taken. QHave any embryonic stem cell studies been funded by the federal government? ANo. Two research projects have been proposed, but NIH consideration has been halted on orders of President Bush, who asked that the 1999 regulations be reviewed. QWho opposes embryonic stem cell research? ASome members of Congress have proposed legislation that would forbid federal funding of such research on moral grounds. Some anti-abortion groups oppose the research because extracting the stem cells requires the death of a human embryo. Pope John Paul II has said injury or death of a human embryo "is not morally acceptable" even though it may advance research that would cure or treat disease. QWho favors federal funding for embryonic stem cell research? AThe majority of research organizations in the U.S., plus 80 Nobel Prize winners, have signed a petition endorsing the research. Scores of scientific societies have announced their support. Many members of Congress also support the research, citing potential benefits for millions of patients. Sun Herald http://web.sunherald.com/content/biloxi/2001/07/05/nation_world/0705_stem_cell_qa.htm * * * ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn