This is an unsettling account of the impact of the political controversy and the lack of US governement funding, on the researchers themselves ... " To researchers ... the controversy means that what should be a blossoming field has instead become marginalized. Instead of a mass effort to make healthy blood, brain tissue, and other organs from stem cells, just five or six labs scattered between Harvard and MIT work with the cells at all." FROM: The Boston Globe July 3, 2001, Tuesday ,THIRD EDITION SECTION: NATIONAL/FOREIGN; Pg. A1 HEADLINE: FEAR, POLITICS SLOW STEM-CELL WORK By Raja Mishra, Globe Staff Dr. George Daley of the Massachusetts Institute of Technology sees magic in embryonic stem cells. He sees cures. But when he surveys the test tube-lined halls of Boston and Cambridge, he sees fear. Grad students are not rushing into stem-cell research. Labs are not bursting with funding and discovery. Embryonic stem cells - highly flexible cells with the potential to morph into any human tissue - were supposed to be the Next Big Thing, and the medical powerhouses here were supposed to lead the field. But instead of focusing on petri dishes, the few local scientists such as Daley who venture into the research fret about politics. And they speak in hushed tones about their funding sources. In the coming weeks, President Bush will decide whether taxpayer money can be used to fund embryonic stem cell work. Because stem cells are harvested from discarded embryos and fetuses, antiabortion activists equate the harvesting to partial-birth abortion and they warn of protests and pickets. To researchers such as Daley, the controversy means that what should be a blossoming field has instead become marginalized. Instead of a mass effort to make healthy blood, brain tissue, and other organs from stem cells, just five or six labs scattered between Harvard and MIT work with the cells at all. "I don't feel like I should have to justify this area of inquiry to anyone. It's so patently obvious to me how exciting and valuable it is," said Daley, who studies using stem cells to treat leukemia patients. "There should be dozens if not hundreds of labs working on this as opposed to a handful." The debate started almost immediately after the initial embryonic stem cell breakthrough in late 1998. James Thomson at the University of Wisconsin announced he had found the long-theorized cells in leftover embryos from a fertility clinic. At about the same time, John Gearhart at Johns Hopkins University in Baltimore found the cells in human fetuses donated by women treated at a local abortion clinic. The scientific community was electrified, and the field of regenerative medicine - helping the body regrow itself - ignited. Stem cells were mentioned alongside the human genome project as a frontier of new millennium science. These cells are key in transforming the single cell formed when sperm fertilizes an egg into the incredibly complex human body. Stem cells can divide indefinitely. Through genetic signals, they eventually specialize, becoming skin, nerves, bones, and the rest of the body. But before specialization, they are pluripotent - possessing the potential to become any tissue. The current debate centers on the fertilized egg four days after conception, when it becomes a mass of several dozen cells called the blastocyst. Researchers wish to harvest the cells from the inner portion of the blastocyst, grow them in a test tube, and figure out how to prompt them to form whatever tissue ailing patients need. Potential applications include Parkinson's disease, Alzheimer's disease, heart disease, diabetes, stroke, burns, and spinal injuries. But for those who believe life begins at conception - the single initial cell - harvesting blastocyst cells is tantamount to murder. After the furor over the initial discovery in 1998, the Clinton administration reviewed the ethics of stem cells, and gave out no federal grants for stem-cell research. A cloud hung over the field. "The lifeblood of a field is federal funding. Without federal funding it's hard to grow a program," said MIT's Daley. Late in President Bill Clinton's second term, the National Institutes of Health decided to fund research using stem cells gathered from embryos at fertility clinics that were going to throw them out anyway. Aborted fetus stem cells were out. Almost immediately after taking office, Bush suspended the NIH decision and asked his administration to review it. Many of his health advisers, led by Health and Human Services secretary Tommy Thompson, are urging him to approve the Clinton administration's standard. Some of Bush's staff members, such as White House chief political adviser Karl Rove, advise against it, worrying that conservative and Catholic voters will be angered. But in Congress, where lawmakers will challenge Bush if he enacts a ban, some fervently antiabortion legislators have publicly supported embryonic stem cell work. Republican Senate leaders Trent Lott of Mississippi and Orrin Hatch of Utah are this faction's most influential members. To date, the federal government has funded no embryonic stem-cell research. But that doesn't mean it hasn't occurred. The initial cells harvested by the University of Wisconsin and Johns Hopkins were allowed to proliferate in lab gels. About a dozen "families" of these cells are thought to exist, though there is no accurate count. The cells are now entirely under the control of private entities. An alumni association at the University of Wisconsin set up WiCell, a nonprofit that has sold the cells to 30 researchers for $5,000 per sample. The nonprofit mostly funds research but also makes money by running a boat company in Wisconsin and selling commercial real estate there, according to tax forms. Also, scientists in Australia, Israel, and Singapore succeeded last year in harvesting the cells. They formed a company called ES Cell Australia Ltd. And an Israeli nonprofit also joined the game. Several researchers, including some in the Boston area, contract with them. "I think it's unfortunate if access to this material is limited to the private sector. It will do harm to patients in the long run," said Dr. Evan Snyder of Children's Hospital, who studies stem cells and neurological damage. "No scientist will have access to critique data. It would not be exposed to rigorous peer-review." Snyder is actually free from the current controversy: Instead of getting his cells from embryos, he's made an arrangement with a local hospital to get them from preserved fetuses from abortions. But embryonic stem cell research is controversial enough that even the researchers themselves don't know exactly who is involved in the work. "I honestly don't know who around here has used them other than us," said Bob Langer, an MIT professor and a leader in the biochemistry field, who gets his stem cells from Israel. "If more good work was going on, it would be good for the field. It would make the field move faster." In fact, if Bush enacts a ban on federal funding for the research, several local companies may get into the business of harvesting and selling the cells. "We were thinking about getting into" the sale of stem cells, said Robert Lanza of Worcester's Advanced Cell Technology, who nonetheless has urged the White House to allow federal funding. But now the issue is slowly but surely bubbling up among antiabortion activists. If Bush allows funding, it would likely become a hot-button topic, much like so-called partial birth abortion, a procedure sometimes used in late-term abortions, said local antiabortion activists. "It's conceivable that our members may picket these scientists," said Ray Neary, executive director of Massachusetts Citizens for Life, with 20,000 members in the state. "I don't look very highly upon these scientists." Daniel Avila, with the Massachusetts Catholic Conference, which represents the Commonwealth's four Catholic dioceses, said: "My sense is that there is no difference among activists between abortion clinics and stem-cell research." The brewing storm has led Daley to occasionally shed his lab coat to travel to the halls of power, meeting with senators and lobbyists in Washington. "Is it a distraction? Yes. But I feel a responsibility to respond," he said. SIDEBAR: SOME KEY QUESTIONS AND ANSWERS What are embryonic stem cells? Unlike most cells, stem cells can divide indefinitely and turn into any tissue in the body. The vast majority of cells in our bodies are locked into being a single type of tissue, such as brain cells or heart cells. Where do they come from? The most versatile stem cells - called pluripotent stem cells - are present in the first days after an egg is fertilized by sperm. They are also present in some fetal tissue. What can they be used for? Researchers believe they can coax stem cells to become whatever tissue patients need. They could be used to repair organs damaged by disease or injuries. The cells might help treat Parkinson's disease, Alzheimer's disease, damaged hearts, burns, diabetes, leukemia, and spinal cord damage. Who is against using them? Why? Those who believe life begins with conception. In the view of some antiabortion advocates, gathering cells from embryos is the moral equivalent of abortion, which they view as murder. How would Bush's decision affect stem cell research? Bush is considering whether taxpayer money should fund the research. Most types of medical research receive government funding. If Bush approves embryonic stem cell research, dozens of scientists are likely to apply for grants to pursue stem cell work, and the field will grow. If he decides to ban it, the size of the field will be limited and be run, in large part, by private companies and overseas researchers. ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn