July 10, 2001 Scientist's Stem Cell Work Creates Uproar By SHERYL GAY STOLBERG MADISON, Wis., July 6 — When Jonas Salk discovered the polio vaccine, he granted the journalist Edward R. Murrow an interview, appeared in a photo spread in Life magazine, and became an American hero virtually overnight. When Dolly the sheep was cloned, her creator, Ian Wilmut, was featured in news magazines and on television programs around the globe. Few people, by contrast, have ever heard of James A. Thomson. And that is just the way Dr. Thomson likes it. Three years ago, Dr. Thomson, a developmental biologist at the University of Wisconsin, became the first person to isolate stem cells from human embryos. Nobel laureates praised his work as a breakthrough that might revolutionize modern medicine. Conservatives and some religious leaders, notably Pope John Paul II, denounced it as immoral. Now President Bush is considering whether to permit federal financing for the research; current law bans spending taxpayer dollars on such work. And here in Wisconsin, where a private foundation affiliated with the university holds the lucrative patent rights to the cells Dr. Thomson discovered, some legislators are contemplating a ban on future embryonic stem cell work. At the vortex of the controversy is an intensely private, soft-spoken scientist who, by all accounts, including his own, has thought carefully about the ethical implications of his research, as well as the inevitable publicity. That he might wind up in the spotlight so worried Dr. Thomson, he said, that he almost decided not to pursue the work that, many scientists say, holds out the hope for curing diseases as varied as Parkinson's, Alzheimer's and diabetes. But in the end, he said, with characteristic understatement, "I just decided it would be important enough to do it." Everything about Dr. Thompson appears to curve inward. He is stoop- shouldered, with perpetual stubble on his chin, a man who clearly cares little for the trappings of appearance. In the laboratory, he wears rumpled oxford-cloth shirts, khaki pants and a Timex watch with a Velcro band; he dressed no differently when he was called to testify before the United States Senate, an experience that, he admits, left him "scared to death." He shuns most interviews, and all requests to appear on television. ("I don't own a television," he explains, "so why should I support a media I don't like very much?") He shares few personal details, save that on long car trips he often catches himself singing, "The City of New Orleans," a song about a train. He also likes to hang glide. Asked to describe him, his colleagues inevitably chose the same word: quiet. "I'm sure Jamie feels like he would just like to crawl back into his hole and just do science," said Dr. Jon Ordorico, a transplant surgeon at Wisconsin who is collaborating with Dr. Thomson. As R. Alta Charo, a Wisconsin bioethicist whose counsel Dr. Thomson has sought, said, "He wasn't made for this event." Because embryonic stem cells have the potential to grow into any cell or tissue in the human body, scientists say they hold great potential for repairing damaged tissues or organs. But to extract them requires that the embryos be destroyed, and so every year since 1995, Congress has attached language to its appropriations legislation to ban taxpayer financing of the work. The ban requires Dr. Thomson to straddle parallel worlds. He works primarily out of the university's primate center, a pale pink stucco two- story building in an out-of-the way neighborhood of squat apartment houses and clapboard homes here in Madison. This is his federally financed laboratory, where he studies stem cells derived from the embryos of rhesus monkeys and marmosets. But when he conducts research on human cells, he must move to an entirely different laboratory. This one is paid for by the WiCell Research Institute, a corporation set up as a subsidiary of the Wisconsin Alumni Research Foundation, the nonprofit group that holds the patent to Dr. Thomson's work. The location of the WiCell laboratory has never been disclosed, and it is strictly off limits to reporters. "We are concerned about the safety of our employees," explained Carl E. Gulbrandsen, the foundation's managing director. "There are some very radical groups that practice terrorism nowadays." For $5,000, WiCell will send out two tiny vials of human embryonic stem cells to any legitimate scientist who agrees to abide by the institute's restrictions, which include a prohibition on using the cells to create a person. So far, WiCell officials say, about 30 requests have been filled and 60 requests are pending. But in this country, the cells cannot land in any laboratory that buys so much as a light bulb with federal money. Here in Madison, academic researchers have another option: they can work out of the WiCell laboratory. But the facility is cramped, Dr. Thomson said, and so while scientists across the campus are clamoring to collaborate with him, only a handful can. "This in itself is more damaging than the lack of federal grant money," he said. "It really restricts who can do the work and who can't." The son of a certified public accountant and a secretary, Dr. Thomson grew up in the Chicago suburb of Oak Park. As a child, he said, he dreamed of becoming a scientist, having gained experience with a brother who was adept at "blowing things up." But then, he said, "I think most little kids want to be a scientist." One of the great mysteries of life, of course, is how human beings develop from a single cell to an incredibly complex organism, and this is where Dr. Thomson's interests lie. Now 42, he came of age at just the right time to pursue this line of inquiry; in 1980, biologists extracted embryonic stem cells from mice, opening up a whole new look at the development of mammals. Embryonic development, however, is far different in mice than in people, and so Dr. Thomson eventually turned his attention to isolating the stem cells in another species closer to humans: the rhesus monkey. In 1991, he took a job at the Wisconsin primate center. Interested more in research than teaching, he signed on as a staff scientist and began training as a veterinary pathologist, which he said he hoped would provide him some "job security." (Owing to his discovery, he has since been promoted to assistant professor, the lowest rung on the academic ladder.) As he grew closer to isolating the monkey cells, Dr. Thomson said, it became clear to him that the next step would be to do the same in humans. So he sought the advice of Dr. Charo and another Wisconsin bioethicist, Dr. Norman Fost. "He has been fanatically attentive to the ethical issues," Dr. Fost said. "We are lucky that the guy who is the pioneer in all this is such a responsible, thoughtful person." For Dr. Thomson, the moral questions about embryo experimentation were not difficult to resolve; he concluded that research was the "better ethical choice," so long as the embryos, created by couples who no longer wanted to use them to have children, would otherwise be discarded. But he was worried that stem cells might be misused to clone people — a fear that, he said, eventually abated in 1997, when Dr. Wilmut demonstrated by cloning Dolly that embryos were not needed because clones could be produced from adult cells. And he did not like the idea that he might become a public person. So he contemplated leaving to someone else the research in human embryos. But in 1995, days after he published his findings in primates, Geron, a biotechnology company in Menlo Park, Calif., offered to finance the human research. Dr. Thomson, who said he has no financial ties to the company, and owns no stock in it, accepted. Today, Geron retains licensing rights to Dr. Thomson's patents, and is entitled to commercialize his discoveries. Here in Wisconsin at least, Dr. Thomson's fear about becoming a public figure has been realized. In 1999, the year after he announced he had isolated stem cells in humans, Tommy G. Thompson, who was then governor, invited Dr. Thomson to the Capitol in Madison and singled out the researcher for praise. Dr. Thomson described it as a brave move. Now, the former governor is Mr. Bush's secretary of health and human services, and is pressing the president to permit taxpayers to finance research on stem cells. But because the National Institutes of Health, which Mr. Thompson oversees, has refused to release grant money for the research, a number of scientists, Dr. Thomson included, are suing him. The case is titled Thomson v. Thompson. Here in Madison, meanwhile, the Chamber of Commerce, hoping to boost a fledgling biotechnology industry, has come out in support of the embryonic stem cell work. But the State Legislature is considering a ban on experiments that might create additional cell types, or lines — a proposal that is similar to a compromise being considered by Mr. Bush. "Some people say, let's go slow on legislation," said the proposal's author, State Representative Sheryl Albers, a Republican. "I say let's move a little slower on stem cell research, but not cut it off altogether." As the debate continues, Dr. Thomson is trying to focus on his work. "In the fullness of time," he predicted, "the research will go forward. The question is how quickly it will go forward, and where it will be done." -------------------- Bob Martone [log in to unmask] http://www.samlink.com/~bmartone ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn