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> Subject: Re: chronic levodopa use toxic? > From: DIANE/GREG NICOLAOU <[log in to unmask]> > Date: Wed, 11 Jul 2001 18:01:41 -0400 Bravo Janet, Well said. Diane ----- Original Message ----- From: janet paterson <[log in to unmask]> To: <[log in to unmask]> Sent: Wednesday, July 11, 2001 8:04 AM Subject: chronic levodopa use toxic? > hi all > > as far as i have learned, dyskinesias and dystonias > associated with pd and levodopa (sinemet) longterm, > are connected to overmedication of levodopa > as the disease progresses and the response to meds > has to be fine tuned to a greater degree > > in other words, as my neurologist put it, > the 'window' for good symptomatic response > beteween undermedicated 'poverty of movement' > and overmedicated dyskinesia and dystonia > (maybe one could coin the term a 'surfeit of movement') > gets narrower and narrower > > i think the real 'blame' here > lies with pd and its degenerative aspect not the meds > > that is the greatest problem we face at the moment > in re long term management of pd > in my humble opinion > > i like to think of it as fine tuning an aging maserati > (i wish!) > > a sledgehammer approach does not work > > we cannot simply throw more meds at pd > to make the symptoms go away > > > janet > thirteen/sixteen years and still truckin > > janet paterson: an akinetic rigid subtype, albeit perky, parky . > pd: 54/41/37 cd: 54/44/43 tel: 613 256 8340 email: [log in to unmask] . > snail mail: 375 Country Street, Apt 301, Almonte, Ontario, Canada, K0A 1A0 . > a new voice: the nnnewsletter: http://groups.yahoo.com/group/janet313/ . > a new voice: the wwweb site: http://www.geocities.com/janet313/ . > > ---------------------------------------------------------------------- > To sign-off Parkinsn send a message to: mailto:[log in to unmask] > In the body of the message put: signoff parkinsn ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn