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Jacob: On the way to answering you I read Ed Grskovich's reply. At first blush I thought he was suggesting tat GM1 Ganglioside was indeed an agonist. But as I read further I realized that he was saying that Mirapex, which is an agonist, may also have neuroprotective value. In any event, GM1 Ganglioside is not an agonist. Quoting from the abstract of Dr Schneider's (he is the study coordinator) paper, he says in small part "A treatment aimed at rescuing damaged dopaminergic neurons or enhancing the function of residual dopaminergic neurons would be a welcome addition to the PD armamentarium. The monosialoganglioside GM1 may be useful in this regard. GM1 Ganglioside is a complex acid glycosphingolipid that is an important component of mammalian plasma and intracellular membranes" The extract goes on to say much more, some of intelligible to me and some of it not. If you send me either your fax# or your mailing address, I'll get a copy of the paper to you either way. Regards, Paul H. Lauer . ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn