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Proteasomal function is impaired in substantia nigra in Parkinson's disease KS McNaught, P Jenner Neuroscience Letters 2001;297:191-194 Proteasome activity is reduced by a third or more in substantia nigra from patients with Parkinson's disease, according to this study. Proteolytic activity of proteasomes was determined in homogenates from SN tissue of 10 PD patients and seven controls. Compared to controls, the proteasome's three types of proteolytic activity were reduced by 33-42% in patient tissue (P< 0.009), without any difference in cell protein levels. Proteolysis was not inhibited by levodopa even at ten million times the therapeutic concentration, ruling out dopaminergic treatment as the source of reduced activity. The authors note, "Although this is the first report of impaired proteasomal function in PD, it is consistent with recent findings of 28-48% reduction in proteasomal activity in cortical regions of Alzheimer's disease (Keller, J Neurochem 2000)". An E-MOVE report on decreased proteasome activity in Huntington's disease is archived at http://www.wemove.org/emove/article.asp?ID=336 Copyright 2000 WE MOVE Editor: Richard Robinson ([log in to unmask]) This service is provided free of charge to the Internet community, courtesy of WEMOVE.org. This document may be freely redistributed by email only in its unedited form. We encourage you to share it with your colleagues. E-MOVE archives, plus information on subscribing, are available at http://www.wemove.org/emove. To unsubscribe, send an e-mail to [log in to unmask], with "unsubscribe e-move" in the message body. E-MOVE is a service of WE MOVE (Worldwide Education and Awareness for Movement Disorders) 204 West 84th Street New York, NY 10024 TEL 800-437-MOV2 TEL 212-875-8312 FAX 212-875-8389 http://www.wemove.org ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn