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[log in to unmask] ----- Original Message ----- From: [log in to unmask] To: [log in to unmask] Sent: Sunday, July 22, 2001 12:33 PM Subject: Parkinson's Research Parkinson's disease as multifactorial oxidative neurodegeneration: implications for integrative management. Kidd PM. Parkinson's disease (PD) is the most common movement pathology, severelyafflicting dopaminergic neurons within the substantia nigra (SN) along withnon-dopaminergic, extra-nigral projection bundles that control circuits forsensory, associative, premotor, and motor pathways. Clinical, experimental,microanatomic, and biochemical evidence suggests PD involves multifactorial,oxidative neurodegeneration, and that levodopa therapy adds to the oxidativeburden. The SN is uniquely vulnerable to oxidative damage, having high contentof oxidizable dopamine, neuromelanin, polyunsaturated fatty acids, and iron,and relatively low antioxidant complement with high metabolic rate. Oxidativephosphorylation abnormalities impair energetics in the SN mitochondria, alsointensifying oxygen free radical generation. These pro-oxidative factorscombine within the SN dopaminergic neurons to create extreme vulnerability tooxidative challenge. Epidemiologic studies and long-term tracking of victims of MPTP (1-methyl-4-phenyl-1,2,3,6,-tetrahydropyridine) poisoning, suggest oxidative stress compounded by exogenous toxins may trigger the neurodegenerative progression of PD. Rational, integrative management of PD requires: (1) dietary revision, especially to lower calories; (2) rebalancing of essential fatty acid intake away from pro-inflammatory and toward anti-inflammatory prostaglandins; (3) aggressive repletion of glutathione andother nutrient antioxidants and cofactors; (4) energy nutrients acetylL-carnitine, coenzyme Q10, NADH, and the membrane phospholipidphosphatidylserine (PS), (5) chelation as necessary for heavy metals; and (6)liver P450 detoxification support. This abstract came from the National Library of Medicine. ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn