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Can someone explain - what is "ergotism" Thanks Joy Graham ........................................ >E-MOVE reports from the 14th International Congress on Parkinson's >Disease, Helsinki July 28-Aug 1. Poster and Platform session numbers refer >to those in the abstract book, published in Parkinsonism and Related >Disorders 2001;7(Supplement). > >High-dose therapy with pergolide--results of a prospective randomized >trial >J Schwarz, G Arnold, T Gasser, HP Hundemer >S-SA-002 > >Thirty-three patients (mean Hoehn and Yahr stage 2.5) on levodopa and >dopamine agonist therapy received increasing doses of pergolide with >simultaneous reduction of other agonists and levodopa. Baseline doses were >2.5 mg pergolide and 500 mg levodopa. At 24 weeks, doses were 7.8 mg >pergolide and 258 mg levodopa. Twenty-seven patients completed the trial; >2 patients dropped out for lack of efficacy, and 1 patient required >hospitalization for psychosis. Motor symptoms on UPDRS part III improved >from 26 at baseline to 22 at 24 weeks (p=0.01), with specific effect on >tremor. Neither dyskinesias nor activities of daily living were >significantly affected. Adverse events included anxiety, hallucinations, >weakness, abdominal pain, and edema. > >Dr. Schwarz noted that many patients have remained on high-dose pergolide >for several years, although 2 developed ergotism requiring a reduction in >dose. > >Other E-MOVE reports on pergolide for PD are archived at >http://www.wemove.org/emove/article.asp?ID=223 >http://www.wemove.org/emove/article.asp?ID=119 > > >Supported by Eli Lilly >--- >Funding for E-MOVE meeting reports is provided in part by unrestricted >educational grants from Allergan Inc., Elan Pharmaceuticals, and Pharmacia >Corporation. > >Copyright 2000 WE MOVE >Editor: Richard Robinson ([log in to unmask]) > >This service is provided free of charge to the Internet community, >courtesy of WEMOVE.org. This document may be freely redistributed by >email only in its unedited form. We encourage you to share it with your >colleagues. > >E-MOVE archives, plus information on subscribing, are >available at http://www.wemove.org/emove. >To unsubscribe, send an e-mail to [log in to unmask], >with "unsubscribe e-move" in the message body. > >E-MOVE is a service of WE MOVE (Worldwide Education and Awareness for >Movement Disorders) >204 West 84th Street >New York, NY 10024 > >TEL 800-437-MOV2 >TEL 212-875-8312 >FAX 212-875-8389 >http://www.wemove.org > >---------------------------------------------------------------------- >To sign-off Parkinsn send a message to: mailto:[log in to unmask] >In the body of the message put: signoff parkinsn Bob & Joy Graham 37 D Fremantle Village Lot 1, Cockburn Rd South Fremantle WA 6162 Australia Ph & Fax (08) 9430 4730 ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn