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Rees, Unfortunately apomorphine is not yet available in the US. It has been used for years in Europe with great success. I am taking it as part of a clinical study. It is injected into your thigh or stomach. My understanding is that it is a dopamine agonist which targets two completely different dopamine receptors. Sinemet effects receptors 1 and 2, and apomorphine effects dopamine receptors 3 and 4. Don't quote me but it's is something like that. The study lasts a year. My year is up Aug. 8. Hopefully, it will be approved soon. It really works once you get past the nausea, which is controlled by medication the first several weeks. The only other drawbacks are that it is short acting and must be injected. Greg 48/35/35 ----- Original Message ----- From: Rees Jenkins <[log in to unmask]> To: <[log in to unmask]> Sent: Tuesday, July 31, 2001 12:40 AM Subject: Re: Sinement question > Greg, > > Could you tell a little more about the apomorphine that you inject in your > feet? I'm asking because my left foot often clenches up whenever I try to > walk or jog for more than a quarter mile. It also happens often on the > exercise bike. I've complained to two neuros about it, and the only answer I > could get was to take an extra half-tab of Sinemet (which helps, i.e. the > distance goes up to one-half to three-quarters of a mile). It seems like > more Sinemet would be the answer, but I'm trying to hold my Sinemet intake to > a minimum. The neuros didn't suggest it either. One neuro said that the > next step was a muscle relaxer. I don't want to a general muscle relaxer > because I fear that it would interfere with my other activities. Is your > apomorphine like a specific muscle relaxer? > > Thanks, > > Rees Jenkins > > ---------------------------------------------------------------------- > To sign-off Parkinsn send a message to: mailto:[log in to unmask] > In the body of the message put: signoff parkinsn ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn