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CNN
Human cloning attempt to be outlined Tuesday
August  7, 2001 Posted:  2:02 AM EDT (0602 GMT)

Zavos: "We intend to do it right or not do it at all."

WASHINGTON (CNN) -- Discounting fears of critics who argue
the technology is not ready, a team of reproductive specialists is
expected to announce plans Tuesday to clone up to 200 human
beings.

Dr. Panos Zavos, a former University of Kentucky researcher,
said Monday he plans to begin transferring DNA from the
nuclei of living cells into human eggs in November to create
a human embryo, which would be implanted into a woman's
uterus.

"We do intend to do this, and we do intend to do it right,"
Zavos told CNN. Although critics have warned that attempts
to clone animals have resulted in a high rate of ill or deformed
clones, Zavos said, "We intend to do it right or not do it at all."

The announcement will be made at a cloning conference held
by the National Academy of Sciences in Washington, he said.

Zavos is a retired professor and head of a Lexington-based
private corporation that markets infertility products and
technologies. He said his team is working with 200 couples
who are infertile and the aim of the "attempt" is to help them
have a baby.

Zavos said the couples participating in the experiment are
from "all over," including the United States, Britain, France,
Italy and Japan.

Zavos said Dr. Severino Antinori, the Italian doctor who
helped a 62-year-old woman become pregnant in 1994, would
also be involved in the project. Antinori is director of Rome's
International Associated Research Institute. Zavos and
Antinori hope to begin their cloning program using 200 infertile
couples.

But since the House of Representatives has voted to ban
all human cloning and the Senate likely to follow suit, Zavos
said the attempt would be made outside the United States
in one of two countries that have not moved against human
cloning research. He did not disclose where the attempt
would be made.

"The United States is a great country, but this is not the
place to be at this time," he said.

No human has been cloned yet. The most successful
attempts at cloning have been with sheep, cattle and mice.
But cloning sheep has so far been an inexact science,
and fertility experts warn that human cloning presents
a high risk of miscarriage, stillbirth or producing a disabled
child.

Zavos: Cloning 'part of human evolution'
Of the animals cloned so far, some had shown abnormal
growth rates, others have had abnormalities, and some
have unexpectedly died, University of Pennsylvania
bioethicist Art Caplan said. Caplan said called Zavos'
proposal "barbaric human experimentation."

"The way this science is now, it's not working well in
animals," he said. "You don't want to do it in people."

But Zavos said his team believes they have the science
to successfully clone an embryo and implant it in each
woman in the project.

"This is part of human evolution," Zavos said. "We feel
that if we educate the people that we are real people
attempting to assist childless couples in having a child,
everybody understands this and everybody needs this."

Although Zavos and Antinori have not disclosed what
methods they will use, it is believed the technique they
will try is similar to the technique that produced Dolly,
the world's first cloned sheep.

The technique would involve taking DNA from a cell
and implanting it into an egg that would then be placed
in the mother's uterus. The resulting child would be a
carbon copy of the person from whom the DNA was
extracted.

Dr. Ian Wilmut, who created Dolly, said it took 277 tries
to get it right in a sheep. Wilmut does not support human
cloning.

U.S., European authorities oppose plans
The prospect of human cloning faces opposition not
only from researchers and scientists, but from U.S.
political leaders.

On July 31, the House voted to ban all human cloning
on a 265-162 vote. Senate Majority Leader Tom Daschle
has indicated he opposes human cloning as well.

President Bush, who is considering whether to allow
the use of federal funds for stem cell research, also has
come out against human cloning. White House
spokesman Scott McClellan said he was not aware
of the specific procedure that Zavos is expected to
announce.

"If the purpose is cloning a human being, the president
is opposed to any efforts to do that," he said.

And Italian medical authorities have warned that Antinori
risks losing his right to practice in Italy if he presses ahead
with his human cloning experiments. Italy's medical code
stipulates that medical experimentation is allowed only
for the prevention and correction of medical problems.

The Italian medical association has already launched
disciplinary action against Antinori for his stated plans,
which would also violate a Council of Europe convention
prohibiting human cloning that came into force in March.

Another organization, known as Clonaid, has moved its
research into human cloning abroad. Clonaid was founded
by members of a religion called the Raelian movement,
which believes that extraterrestrial scientists created life
on Earth and that cloning is a way of achieving eternal life.

It has been the subject of a Food and Drug Administration
probe after its research director, Brigitte Boisselier, told
a congressional hearing that the company wanted to clone
a human in the United States.

SOURCE: CNN
http://www.cnn.com/2001/HEALTH/08/06/human.cloning/index.html

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