The following are excerpts from a number of newspaper articles found on Lexis-Nexis news database: FROM: AP Online August 10, 2001; Friday 6:40 PM, Eastern Time SECTION: Washington - general news HEADLINE: Scientists Begin Stem Cell Work BYLINE: LAURA MECKLER "... At the National Institutes of Health on Friday, researchers were beginning to catalogue the existing stem cell lines, which officials now estimate at 60 worldwide. Around the country, scientists were beginning to hone their ideas for grant applications, which were expected to be submitted and awarded by early next year. Dr. Harold Varmus, who led the NIH under President Clinton, predicted that hundreds of researchers would get into the field, even under limited federal funding. Ultimately, he predicted that the federal government would spend tens to hundreds of millions of dollars per year in this field." " Dr. Catherine Verfaillie, who directs the University of Minnesota Stem Cell Institute, said the political turmoil surrounding this research dissuaded her from applying for federal funding when it was initially offered last year. ''Many investigators were in the same boat,'' she said. But now that the matter appears settled, she plans to submit a grant application..." FROM: Newsday (New York, NY) August 11, 2001 Saturday ALL EDITIONS SECTION: NEWS, Pg. A06 HEADLINE: Scientists Cautious On Limits To Work By Jamie Talan; STAFF WRITER "Scientists expressed concern but also cautious optimism Friday about President George W. Bush's decision to allow limited public funding for research using embryonic stem cells. "This is a compromise I'm not totally happy with," said Dr. Harold Varmus, former director of the National Institutes of Health and now president and chief executive officer of Memorial Sloan-Kettering Cancer Center in New York. "Placing these kinds of limits is something we, as scientists, don't like to do. Inevitably, there will be a need for more [stem cell] lines." "... Fred Gage, a renowned stem cell researcher at the Salk Institute in La Jolla, Calif., also expressed concern about the limited number of cell lines. He spent Friday fielding calls and e-mail messages from colleagues who want to know what the new policy will mean for their research. "I still don't know whether the human ES [embryonic stem] cells will be made available, and how that will happen," said Gage, the scientist credited with finding populations of adult stem cells in the brains of patients who died of cancer. "Right now, most people want to know where the 60 cell lines [mentioned by Bush] come from." Gage said that though he wants to work with embryonic stem cells, he hasn't pursued obtaining any because federal funding guidelines have been confusing. He said he was among at least 80 scientists interviewed by NIH officials for a report that helped shape Bush's decision. Many of the scientists on this list say they remain in limbo. "I want to know what the guidelines would allow me to do - starting tomorrow," said Dr. Mahendra Rao, a section chief at the National Institute on Aging who was studying embryonic stem cells at the University of Utah. When he arrived at the federal institute in May, he knew he'd have to leave his human embryonic stem cells behind because of the NIH guidelines, but he says he hopes to work with embryonic stem cells again. "These cells are a huge resource," Rao said. "We must understand how they work. If we give this over to industry with a profit motive, we may never get this information at all." Rao was among a handful of U.S. scientists funded by Geron Corp., a California biotech company that has dozens of patents on the human embryonic stem cell technology. "We have been frustrated in our own ability to work with more top scientists," said Dr. Thomas Okarma, Geron's president and chief executive. The cell lines that Geron is developing originally came from Dr. James Thomson of the University of Wisconsin. Geron funded Thomson's pioneering work. Okarma added that the company now has created distinct cell types - liver, nerves and heart muscle - from the three germ layers of the human embryo. "Stem cells hold great promise for innovative medical therapy," said Dr. Mark H. Tuszynski of the University of California in San Diego. "I'm heartened that the opinion of the minority did not block the potential to do good for the majority." However, scientists worry the restrictions will result in the research winding up solely in the hands of private companies or scientists outside the country..." FROM: The San Francisco Chronicle AUGUST 11, 2001, SATURDAY, FINAL EDITION SECTION: NEWS; Pg. A11 HEADLINE: Researcher worries about limits of policy; Some key areas of research still can't be pursued BYLINE: Tom Abate "In his first interview since deciding to move his laboratory out of the country, noted stem cell researcher Roger Pedersen offered a good news-bad news assessment of President George Bush's policy of limited support. Pedersen, who has said he is moving to Britain because of political uncertainties about the future of stem cell research in the United States, deflected any discussion of whether he might reverse his decision to leave the University of California at San Francisco...." "... Specifically, he said the Bush policy effectively allows U.S. scientists to pursue only one of the three avenues of research that are essential to turning stem cells into medicines. The first area is known as differentiation, referring to how stem cells are able to turn into any of the 200 cells of the body, including blood, bone, muscle and nerves. Pedersen said controlling the process of differentiation is the first task scientists must accomplish to make stem cell medicines. "It's plausible that this opening (provided by the Bush policy) will provide insight into this first question of differentiation," Pedersen said. "The bad news is that it won't provide as much insight into the other two problems." Another problem is immune rejection. If stem cells are ever developed into treatments for disease, such as diabetes or Alzheimers, they will need to match the immune system of the patient. Otherwise, the body will reject them. Pedersen said 60 cell colonies are far too few to develop stem cell treatments that won't be rejected. He was not certain how many new cell colonies scientists would have to create in order to ensure a close match to all immune system types. "I can't get a straight answer from the immunologists," he said. "It is between hundreds and thousands of cell lines." The third problem is ensuring that any cells that are transplanted into human beings are not contaminated with foreign viruses. Before any stem cell treatment can be transplanted into a human subject, the U.S. Food & Drug Administration will require that the original stem cell culture was made according to "good tissue practices," he said. Among other things, Pedersen said these FDA rules require that there is no contamination from other species. He said the embryonic cell lines that have been described in scientific papers used mouse cells to provide nutrients. Some were exposed to extracts from cow's blood. "They (the existing cell lines) do not at first glance seem to meet good tissue practices," Pedersen said, and therefore could probably not be used to produce even experimental cell-based medicines. "That's why you need to make more cell lines...." FROM: Washington Post August 11, 2001, Saturday, Final Edition SECTION: A SECTION; Pg. A10 HEADLINE: Bush Stem Cell Policy Cools Fervor on Hill BYLINE: Amy Goldstein, Washington Post Staff Writer "... Yesterday, an administration official said Bush may have settled on his decision Aug. 2, when he met with NIH scientists who reported that they had canvassed researchers and companies in the United States and abroad and located at least 60 stem cell lines, twice as many as the institutes had suggested were in existence last month. The discovery implied to the president that the existing cell lines could provide enough material for researchers to make significant progress. Jay Lefkowitz, who attended many of Bush's meetings on stem cells in his role as general counsel of the Office of Management and Budget, said the president considered the five dozen cell colonies "exciting news" because it would "provide a great deal of opportunity for research." Some scientists yesterday questioned whether that many cell colonies exist. But Health and Human Services Secretary Tommy G. Thompson said he expected NIH would continue to discover lines that had been created as of Aug. 9, the date of Bush's announcement. Speaking at an afternoon news conference at the institutes' Bethesda campus, Thompson said NIH yesterday began to create a registry of the known cell lines and was beginning to design a process that would enable them to be shared among researchers. At least one scientific leader in the field, James Thomson, the University of Wisconsin researcher who discovered human embryonic stem cells in November 1998, said he was satisfied with Bush's approach. "People have said they want dozens of cell lines. Well, 60 is dozens," Thomson said. "Even if some of those are no good, there's still going to be a lot to work with." FROM: Los Angeles Times August 11, 2001 Saturday Home Edition SECTION: Part A; Part 1; Page 1; National Desk HEADLINE: THE NATION; Stem Cell Decision Doesn't Quell Debate; Science: Uncertain but resolved researchers gear up to start limited tests. Senate hearing planned. BYLINE: AARON ZITNER, EDWIN CHEN, TIMES STAFF WRITERS "...scientists and research advocates said they need to know much more, including the conditions under which the cell lines were created, their ability to reproduce and whether they could truly grow into a wide range of body tissues. "We know that not all embryonic stem cell lines are the same," said Dr. Robert Lanza, a vice president at Advanced Cell Technology Inc., a Massachusetts biotechnology firm. "Some grow at a rate that's so slow that it's not of value. Some lines can be impossible to get neurons or brain cells from." Ronald Green, an ethics professor at Dartmouth College who has written widely on the issue, said that "in mouse embryonic research, about half the lines are no good. They don't proliferate well." "... Some researchers noted that obtaining stem cells from private companies has been a frustrating experience. Private firms often ask for certain rights to discoveries made with their cells, but researchers and universities do not want to sign away the power to control or profit from their work. HHS Secretary Thompson acknowledged the problem but said it could be overcome. "We still have some very strong proprietary and patent issues to work through, but I have great confidence that they can be addressed." He said he talked Thursday to a nonprofit business that owns rights to five cell lines and was encouraged by its willingness to cooperate with researchers. The Bush plan also might help academic researchers work with stem cells using private funds. Many universities had discouraged their scientists from working with embryonic stem cells on campus because it would mingle federally funded work with research not eligible for federal money. Administrators worried that the NIH would penalize them for using federal money to pay even for light bulbs or secretarial help devoted to stem cell work. But the NIH is now reviewing its rules for such shared overhead costs." "...Doctor Predicts Pace of Research to Pick Up "...NIH officials said they cannot predict how many researchers will be drawn into stem cell research because of Bush's plan, but they are optimistic. Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, said the pace of research will speed up "enormously." Within a decade, he predicted, the field will produce "substantive treatments for some diseases. You're going to see clinically relevant results." "... several researchers praised Bush for lifting the cloud that had hung over the field. "Six months ago, this was all going to be stopped [by the Bush administration], and now it's going to go forward," said Thomson, the University of Wisconsin researcher. "This is not perfect from a scientific view, but it's not going to be stopped dead in the water." ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn