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Hi Linda and all ...... Thanks for your letter. I was dx about a year ago and have taken Requip, Mirapex and Sinemet (300mg a day) No effect whatsoever. I'm 46 yrs old and work full time. I have right side movement difficulty. Foot dragging, no arm swing. Dexterity stinks - handwriting is awful. My local neurologist recently referred me to Indiana University Hospital MDS Xabier Beristain, after the above list of meds produced no results. Mike In a message dated 8/21/2001 7:36:51 AM Eastern Daylight Time, [log in to unmask] writes: << Mike, You asked: <<My MDS has prescribed SinemetCR By the third week I'll be at 800mg a day Is anyone on this high of a dose? Side effects?>> Are you newly diagnosed? There's been a number of current research reports suggesting that other meds,, such as dopamine agonists be tried first for newly diagnosed and sinemet added when needed at low doses to start, especially for younger PWP. But medication for PD is very individual - it depends on many factors -- your symptoms; other PD drugs -- are you taking a dopamine agonist such as Mirapex or Requip or other PD medications as well?; are you already taking Sinemet?; have you tried lower doses; what is your age, how long since you've been diagnosed; are you working?, etc. I'd suggest you ask this question, giving all of the above information, and anything else about yourself or your symptoms that might be relevant, to "Ask Dr. Lieberman" at the NPF website: http://www.parkinson.org/ I'd also add that if you have any questions about your treatment, your MDS should be willing to discuss them with you. If you feel that your questions are being discouraged or you are not getting understandable answers - ask for a second opinion, or think about finding a different neuro. Linda >> ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn