List:
Human embryomic stem cell research is legal in Sweden
and they are working on application to Parkinsons treatment.
"Alternatve sources" implies the next step in researching
transplantation is being considered, and fetal grafts
have been taken as far as they will go, and improvements
to optimize transplant procedures lie ahead.
Goals are being defined.
Ray
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J Neuropathol Exp Neurol 2001 Aug;60(8):741-52
Cell survival and clinical outcome following intrastriatal transplantation in
Parkinson disease.
Hagell P, Brundin P.
Department of Clinical Neuroscience, University Hospital, Lund University,
Sweden.
Intrastriatal transplantation of embryonic dopaminergic neurons is currently
explored as a restorative cell therapy for Parkinson disease (PD). Clinical
results have varied, probably due to differences in transplantation methodology
and patient selection. In this review, we assess clinical trials and autopsy
findings in grafted PD patients and suggest that a minimum number of surviving
dopaminergic neurons is required for a favorable outcome. Restoration of
[18F]-fluorodopa uptake in the putamen to about 50% of the normal mean seems
necessary for moderate to marked clinical benefit to occur. Some studies
indicate that this may require mesencephalic tissue from 3-5 human embryos
implanted into each hemisphere. The volume, density and pattern of fiber
outgrowth and reinnervation, as well as functional integration and dopamine
release. are postulated as additional important factors for an optimal clinical
outcome. For neural transplantation to become a feasible therapeutic alternative
in PD, graft survival must be increased and the need for multiple donors of
human embryonic tissue substantially decreased or alternate sources of donor
tissue developed. Donor cells derived from alternative sources should
demonstrate features comparable to those associated with successful implantation
of human embryonic tissue before clinical trials are considered.
Publication Types:
Review
Review, tutorial
PMID: 11487048 [PubMed - indexed for MEDLINE]
.......................................................
Ray Strand
Prairie Sky Design
-----------------( on the Edge of the Prairie Abyss )---------------
when the sky is clear
the ground is visible
49/dx PD 2 yrs/40? onset
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