List:
More alternatives to stem cells. With increased understanding of these cells
and research techniques, there will be convergence of optimal therapeutic
techniques.
Here are another form of cell for transplantation (adult stem cells).
This is still an animal model, but, they talk of the next step to humans.
Ray
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J Neurosci Res 2001 Aug 15;65(4):284-8
In vitro generation and transplantation of precursor-derived human dopamine
neurons.
Sanchez-Pernaute R, Studer L, Bankiewicz KS, Major EO, McKay RD.
Laboratory of Molecular Medicine and Neuroscience, NINDS, NIH, Bethesda,
Maryland.
The use of in vitro expanded human CNS precursors has the potential to overcome
some of the ethical, logistic and technical problems of fetal tissue
transplantation in Parkinson disease. Cultured rat mesencephalic precursors
proliferate in response to bFGF and upon mitogen withdrawal, differentiate into
functional dopamine neurons that alleviate motor symptoms in Parkinsonian rats
(Studer et al. [1998] Nat. Neurosci. 1:290-295). The successful clinical
application of CNS precursor technology in Parkinson disease will depend on the
efficient in vitro generation of human dopaminergic neurons. We demonstrate that
human dopamine neurons can be generated from both midbrain and cortical
precursors. Transplantation of midbrain precursor-derived dopamine neurons into
Parkinsonian rats resulted in grafts rich in tyrosine hydroxylase positive
neurons 6 weeks after transplantation. No surviving tyrosine hydroxylase
positive neurons could be detected when dopamine neurons derived from cortical
precursors were grafted. Our data demonstrate in vitro derivation of human
dopamine neurons from expanded CNS precursors and encourage further studies that
systematically address in vivo function and clinical potential. Copyright 2001
Wiley-Liss, Inc.
PMID: 11494363 [PubMed - in process]
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Ray Strand
Prairie Sky Design
-----------------( on the Edge of the Prairie Abyss )---------------
when the sky is clear
the ground is visible
49/dx PD 2 yrs/40? onset
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