Hi David-- David Meigs wrote: > > Ray, > > Do you ever monitor the PD list (PIENO)? There were a few who had been a > part of the fetal implant studies. One that I remember for sure is Dr. > Charles Meyer (psychiatrist) Charlie had some bad dyskensias because of it. I try to pay attention, but didn't realize Dr. Charles Meyer had a transplant. There is another person, a woman, wrote articulate reply to New York Times article, thought I had squirreled it away,but can't find it now -- > I remember another couple who had the "placebo" surgery. I believe they > declined having the implants later when they were given the chance because > of the unpredictable outcomes. > > Another person on the PD list is Jim Finn. He has done extremely well with > the "Pig cell" transplant he had done a couple years ago. His results have > been phenomenal. Yep, he's famous. > Besides the age factor with the fetal cell transplants, I think the biggest > factor was the amount & area of placement of the fetal cells. Is this a new batch of implants? doubt it. or, is this reworking of the statistics from the first time around? > Take care, > > David Meigs > [log in to unmask] > Meigs Family Webpage: > http://home.earthlink.net/~davidmeigs/index.html > ----- Original Message ----- > From: "Raymond Strand" <[log in to unmask]> > To: <[log in to unmask]> > Sent: Saturday, August 25, 2001 10:43 AM > Subject: PMID: transplantation -- Freed still at it > > Hello list: > > Stem cells have been at the forefront, but, > here is another example alternative cell transplant experimentation. > > You will recall that the 3 year follow up study of fetal implants > by Freed indicated differences between age groups in how well > the implant survived. This study addresses that. > Freed is one of the authors. > > I am curious about the details of "embryonic dopamine cell implantation". > Not stem cells, but, embryonic. > > Ray > > ....................................................... > Ann Neurol 2001 Aug;50(2):181-7 > > Blinded positron emission tomography study of dopamine cell implantation for > Parkinson's disease. > > Nakamura T, Dhawan V, Chaly T, Fukuda M, Ma Y, Breeze R, Greene P, Fahn S, > Freed > C, Eidelberg D. > > Functional Brain Imaging Laboratory, North Shore-Long Island Jewish Research > Institute, Manhasset, NY 11030, USA. > > We assessed nigrostriatal dopaminergic function in Parkinson's disease (PD) > patients undergoing a double-blind, placebo-controlled surgical trial of > embryonic dopamine cell implantation. Forty PD patients underwent positron > emission tomography (PET) imaging with [18F]fluorodopa (FDOPA) prior to > randomization to transplantation or placebo surgery. The 39 surviving > patients > were rescanned one year following surgery. Images were quantified by > investigators blinded to treatment status and clinical outcome. Following > unblinding, we determined the effects of treatment status and age on the > interval changes in FDOPA/PET signal. Blinded observers detected a > significant > increase in FDOPA uptake in the putamen of the group receiving implants > compared > to the placebo surgery patients (40.3%). Increases in putamen FDOPA uptake > were > similar in both younger (age < or = 60 years) and older (age > 60 years) > transplant recipients. Significant decrements in putamen uptake were > evident in > younger placebo-operated patients (-6.5%) but not in their older > counterparts. > Correlations between the PET changes and clinical outcome were significant > only > in the younger patient subgroup (r = 0.58). The findings suggest that > patient > age does not influence graft viability or development in the first > postoperative > year. However, host age may influence the time course of the downstream > functional changes that are needed for clinical benefit to occur. > > PMID: 11506400 [PubMed - in process] > > ....................................................... > Ray Strand Prairie Sky Design -----------------( on the Edge of the Prairie Abyss )--------------- when the sky is clear the ground is visible 49/dx PD 47/40? onset ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn