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Barbara, I try to spread my Sinemet CR out over the day in five hour periods (6am, 11am, 4pm, 9pm). However frequently I wake up in pain and very stiff early in the morning. Taking a 1/2 dose of Sinemet before going back to bed helps me a lot. I have also had problems with Dopamine Agonists (e.g. low blood pressure). It helps me to take Amantadine and reduce the Dopamine Agonists. If I am having problems with dyskinesias or very slow movement, walking around the house and basic T'ai Chi exercises help me get my mind and body together. Have you tried SAM-e (S-adenosylmethionine)? My experience over the past year is that SAM-e seems to extend the effectiveness of my other meds and helps with depression. SAM-e may help my liver process the other meds. I take 400mg of SAM-e in the morning and again in the early afternoon. My re-introduction to this list. I have not been active on the list for a couple of years. I am 50, diagnosed with PD in 1993 after I was misdiagnosed in 1991 with carpal tunnel syndrome in my right arm and old sport injuries in my right leg. My current meds are Selegiline 5mg x 1, Sinemet CR 200-50 x 4, Ropinirole 1MG x 3, & Amantadine 100mg x 2 (with a supplemental 1/2 dose of Sinemet CR if I wake up too early) Charley ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn