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I made the mistake of combining two different things in my message. However, at least in my case, the same remedy works for both, but for different reasons. I find that deliberate movement, such as walking, will alleviate dyskinesias. I like the convenience of Sinemet CR, but the release of medication and its utilization by the body does vary. Sometimes there is too much and the result is dyskinesia. Sometimes there is not enough medication. Deliberate movement is not an immediate help for that. But I think that the affect of PD on the heart and circulatory system needs more emphasis. Basically, I think that sometimes the pump just needs to be primed and deliberate movement serves that purpose. Jorge A Romero MD wrote: > > It is important to separate out the effects of too much treatment from > insufficient treatment. In general, dyskinesias occur when the dose of > Sinemet peaks too high; stiffness and rigidity emerge when the level of > medication drops (trough level) too low to be fully effective. Since > Sinemet (even CR) is a short acting medication, high peaks and low troughs > can occur in the same person. > > > Jorge A Romero, MD > > ----- Original Message ----- > From: "Charles Countryman" <[log in to unmask]> > To: <[log in to unmask]> > Sent: Thursday, August 23, 2001 5:28 PM > Subject: Re: levodopa side effects...need help > > > >>Barbara, >> >>I try to spread my Sinemet CR out over the day in five hour periods >>(6am, 11am, 4pm, 9pm). However frequently I wake up in pain and very >>stiff early in the morning. Taking a 1/2 dose of Sinemet before going >>back to bed helps me a lot. >> >>I have also had problems with Dopamine Agonists (e.g. low blood >>pressure). It helps me to take Amantadine and reduce the Dopamine >>Agonists. >> >>If I am having problems with dyskinesias or very slow movement, walking >>around the house and basic T'ai Chi exercises help me get my mind and >>body together. >> >>Have you tried SAM-e (S-adenosylmethionine)? My experience over the >>past year is that SAM-e seems to extend the effectiveness of my other >>meds and helps with depression. SAM-e may help my liver process the >>other meds. I take 400mg of SAM-e in the morning and again in the early >>afternoon. >> >>My re-introduction to this list. I have not been active on the list for >>a couple of years. I am 50, diagnosed with PD in 1993 after I was >>misdiagnosed in 1991 with carpal tunnel syndrome in my right arm and old >>sport injuries in my right leg. My current meds are Selegiline 5mg x 1, >>Sinemet CR 200-50 x 4, Ropinirole 1MG x 3, & Amantadine 100mg x 2 (with >>a supplemental 1/2 dose of Sinemet CR if I wake up too early) >> >>Charley >> > > ---------------------------------------------------------------------- > To sign-off Parkinsn send a message to: mailto:[log in to unmask] > In the body of the message put: signoff parkinsn > > ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn