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Thank you so very much to your reply-it is so helpful to hear that our family is not alone -or the only ones- in dealing with this. My sister is on antipsychotic meds (Seraquel) as well as Sinemet, amantadine and Mirapex. We all strongly feel-and so does her neurologist-on of the best- that she take a "drug holiday" in a hospitalized setting to titrate off all meds-and then work back in a medical regimen that might be less "toxic" to her and improve overall symptonatology ettc. HOWEVER, my sister is FLATLY REFUSING this option much to our great distress. Part of the problem is that currently, she manages meds on her own and compliance on a daily basis is HIGHLY questionable. She is "on her own" with this since part of her psychological symptoms are extreme paranoia towards her husband-and she thinks, if he is in charge of overseeing medical compliance-that is is tainting or poisoning her meds and thus would refuse to take them all together!!!!! I unfortunately live in Florida, and there is NO family on Portland-we are all on the east coast. My sister does have a caseworker who is a huge help, but she cannot oversee evry medicne my sister takes on a daily basis. My sister has also refused outside help in the form of hired nurse aids, etc. BECAUSE she is still considered competent, her decisions stand. We have pleaded with the family to move here to the east coast, but the husband is an oral surgeon(the family's source of income) and his patient base as well as licensure to practice is for Oregon only. A tough, tough situation for all. Thank you for sharing your experience-Regards, Sharon ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn