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www.ncbi.nlm.gov ----- Original Message ----- From: "lucol" <[log in to unmask]> To: <[log in to unmask]> Sent: Saturday, October 13, 2001 5:35 PM Subject: Re: Has anyone tried SAM-e? > Nilo, > There are several articles relating SAM-e to parkinson's at > www.ncbi.nlm.nih Thanks for raising the question. I bought some today at > Walgreen's and plan to check it out on my own body. Everything I read about > it is favorable. Peace > Carl > > > ----- Original Message ----- > From: "NILO SARMIENTO" <[log in to unmask]> > To: <[log in to unmask]> > Sent: Thursday, October 04, 2001 7:56 PM > Subject: Has anyone tried SAM-e? > > > > last week, i saw my neuro, and asked him about SAM-e; he said he had heard > > a lot of good things about it. I asked him if it would be OK for me to > take > > it. He said, "OK, and let me know what you think of it." > > > > I am currently on sinemet 25/100, 3 times before a meal. Just lately, a > > fellow staff member who is very much into the Vitamin B family asked me if > > I was taking Vitamin B...I said, No. I got curious, and did some reading, > > and found that B6 and B12 was good for the nervous system [excerpt > > below]...and I proceeded to click on the link SAM-e. > > > > To make a long story short, when I receive my shipment of SAM-e 400mg > > tomorrow or early next week, I going to include that as part of my > regimen, > > along with the Vitamin B6 and B12. > > > > if any of you has tried this, i'd like to know from your own personal > > experience what the results have been. > > > > What Will B Complex Do For Me? > > You probably didn't know that the most common nutritional deficiency in > the > > world is folic acid deficiency, which is characterized by low mood, and > can > > lead to neural tube defects in the developing, unborn child. Deficiency in > > either vitamins B-12 or B-6 can also bring about low mood, and often mask > > folic acid deficiency (which is why it is so important to take a > supplement > > that is a complete B-complex). In fact, folate supplementation, which in > > large doses requires a doctor's prescription, is a long standing treatment > > in some cases of depression. B vitamins are not stored well in the body > and > > are depleted rapidly in dieters, and caffeine and alcohol users. The > > B-complex is used throughout the body in methylation reactions and is > > particularly effective against low mood, moodiness, muscular weakness and > > fatigue when combined with s-adenosyl methionine (see our SAM-e page for > > more on methylation reactions and SAM-e). > > > > > > > > What Is S-Adenosyl Methionine / SAM-e? > > S-Adenosyl Methionine (SAM or SAM-e; pronounced "sammy") is an amino acid. > > SAM-e was discovered in 1952 in Italy, where it is manufactured. Until > > recently, it was exceedingly expensive to produce, and therefore > > unavailable to the public, although it is fairly well studied. It is > > manufactured in the brain from another amino acid, methionine. SAM-e is > the > > most active methyl-donor in your body, meaning it donates methyl groups to > > other chemical compounds in your body including neurotransmitters, > changing > > them into other compounds. SAM-e is then "recycled" through an ongoing > > re-methylation process - more on this below. > > SAM-e Improves Mood Fast! > > The brain of a healthy person manufactures all the S-Adenosyl Methionine > it > > needs from methionine, but S-Adenosyl Methionine production is impaired in > > people who are depressed.1 Supplementation with SAM-e increases levels of > > serotonin, dopamine and phosphatides, and improves serotonin and dopamine > > receptor site binding.2 Interestingly, treatment with antidepressant drugs > > that results in improved mood (as determined by a 50% improvement in the > > Hamilton Depression Inventory) usually also results in increased levels of > > SAM-e, regardless of the drug used.3 > > > > Perhaps the most striking aspect of supplementation with SAM-e, is its > > rapid onset of action. SAM-e has fewer side effects and has a more rapid > > onset of action than tricyclics.1 > > > > > > 1 Murray, MT, Natural Alternatives to Prozac. Quill. New York. > p174-5,1996. > > 2 Baldessarini, RJ, Neuropharmacology of S-Adenosyl Methionine. Am J Med. > > 83:95-103, 1983. > > > > ---------------------------------------------------------------------- > > To sign-off Parkinsn send a message to: > mailto:[log in to unmask] > > In the body of the message put: signoff parkinsn > > > > ---------------------------------------------------------------------- > To sign-off Parkinsn send a message to: mailto:[log in to unmask] > In the body of the message put: signoff parkinsn ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn