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This has been discussed before,but I wasn't taking it at that time.Right now I'm taking 25/100 of sinement 3 times a day. Because of a slight balance problem I was put on requip .25 mg 3 times a day.this summer took them together, but I was having some nausea. My neuro suggested I take the requip with meals and this seemed to be the solution. In addition to the nausea I had some dizziness.For the last two weeks I've tried to take my sinement at least 45 mins. before meals,which seems to be easy to do before breakfast,but not usually for lunch and dinner. It was suggested that I take the requip every eight hrs to maximize the benefit.Well that's o.k. the first thing in the morniing,but the middle one and the last of the day are done at all times. I am a snacker and have difficulty eating a lot at meals except breakfast.My system seems to tolerate the requip without taking at meals now and I've had only one dizzy spell,which lasted just a few seconds.Also I'm not certain whether my gait is as good later in the day then it was.Well I guess my question is just what is the optimum way to take these two meds--together, spread out, etc? Perhaps Kathryan could answer this. Thanks Lorraine Jeffe ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn