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Hello, On 17 Nov 2001, at 23:07, Kathy Greis wrote: > i've never posted a messege before ... Welcome! > ... I'm taking Sinemet CR 50/200 6x/day, Mirapex 0.5mg 6x/day, > Comtan 200mg 6x/day, Norvasc 2.5mg /day and now premarin .625mg > /day. > ... does anyone else have alot of off and on with their meds? It > doesn't seem to matter if I take them exactly on schedule, I am > either very ridgid and full of tremors or have too much and having > dyskinesia. I had dyskinesia with Sinemet CR. It seemed to me that the CR was releasing too much levodopa over too short a period. My current neuro switched me to regular release, and this reduced dyskinesia significantly. Do your off periods seem worse for the next dose following a meal and in proportion to the amount of protein or fat ingested or the size of the meal? Is your neuro a PD or movement disorder specialist (MDS)? If so, and your diet and meds are tuned to the max, have you discussed the possibility of DBS? If you'e not seeing a MDS, it might be a good idea to consult one about whether your sinemet dose is too strong and/or you would do better with regular release. > My neuro just keeps telling me to keep up with exercise, when i > can, and theres hope around the corner for new treatments in the > coming years. I'm tired of waiting and think i'm starting to get > depressed. Hang in there, and let us hear from you more often. Phil Tompkins age 63/dx 1099 ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn