Hi Carol, You may be taking too much sinemet. Nancy is taking 7 sinemet with 3 permax, 4 comtan and 4 amantadine. If she sticks to a very rigid schedule she seems to do ok. She did have the pallidotomy surgery on both sides and this eliminated the dyskinesia. But she did get both sides done to do accomplish that. Doing only one side helped only one side, the other side was still awful. This was done in 1995. I think now they would recommend DBS/STN on the other side and not palidotomy. Nancy's schedule is: 7:00 am pemax, amantadine, sinemet 9:00 am pemax, amantadine, sinemet, comtan 11:30 am amantadine, sinemet, comtan 2:00 pm permax, amantadine, sinemet, comtan 4:30 pm sinemt, comtan 7:00 pm sinemet 9:00 pm sinemet She alternates sinemet 10/100 and 25/100. generally the 25/100 are non-meal time and the 10/100 are meal time. We use a timer pill box to keep it all straight. With out the timer it is very difficult to stay on schedule. There are times when she experiences freezing and alters the schedule but this seems to cause problems with balance, clear thinking, and just difficult to manage. Sitting through the end of dose freezing and waiting till the scheduled time seems to work best. When she can't sit and wait it out, taking the pill and the related consequences is sometimes the better choice. Night time usually involves 1-3 sinemet cr and this has allowed her to sleep most of the night. She also takes clozaril in the evening Bob Martone [log in to unmask] http://www.samlink.com/~bmartone -----Original Message----- From: Parkinson's Information Exchange Network [mailto:[log in to unmask]]On Behalf Of Carol Gray Sent: Tuesday, November 20, 2001 8:02 AM To: [log in to unmask] Subject: new member Hi everyone. I guess I need to reintroduce myself. I have been off the list for quite a while. I am 60 years old and have had pd for 23 years. I have been having a lot of problems falling recently. My medication is: 10 sinemet 25/100, 5 comtan,3 permax and 4 amantadine. I have a great deal of trouble with dyskinesias. I have had three back surgeries and a pallidotomy within one year's span. The pallidotomy worked well for only 6 months and that seemed to be a very short time to me but I guess everyone is different. I am glad to be back on the list. Carol Gray ---------------------------------------------------- ------------------ To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn