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I am new to the list; my name is Theresa and my father has Parkinson's. My mother is the primary caregiver, I try to support both of them. My dad was diagnosed with PD 4 years ago, but now we know he had it for years before diagnosed. He does not have a tremor so the diagnosis took some time. At that time his doctor put him on Sinemet three times a day (25/100), now he is up to 1150 mg per day (Sinemet reg and Sinemet CR) trying to get relief from freezing and be able to function. I have several questions and would appreciate any and all help! Is this too much Sinemet to be taking? Twenty min. after taking his dose he begins having involuntary movement which lasts for about 1/2 hour, and he has to just sit and wait for the medicine to "kick in" which sometimes it doesn't. Does there come a time when the Sinemet becomes ineffective? He has been given Comtan to try, but has not started it yet. Does anyone take it, is it helpful? Is it recommended - any tips? Thanks so much, Theresa ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn