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I would greatly appreciate finding out what is considered 'safe' for sleep help for PWP's using Sinemet & Eldepryl. Apparently, most of the usual drugs for these problems may not be used. The only class of drugs I have found so far not contra indicated is the Benzodiazepines. My husband, 68, male, PD for 8+ years (Sinemet 10/100 3-4 X day, Eldepryl 5 mg 1 X day) is currently having a horrible time as bedtime comes. He gets anxious and restless. He has somewhat of a phobia about sleep time because he has SO much trouble going to and/or staying asleep (also has all the 'usual' PD nightmares, verbalization, thrashing, etc.) He sleeps little, and intermittently. It is becoming an overwhelmingly disturbing issue for him. I am researching this in several places, but would like to have your input -- what have you used/found to be helpful? He has tried Xanax and Vallium, neither seems to have much of an impact. I believe that an anti-anxiety drug may be a good choice. Before we go back to the Doctor (who is not very helpful) I would like to compile a list of drug possibilities. Therefore, I ask -- what has worked for you -- what would you suggest? Would an 'extra' Sinamet at bedtime be helpful? Thank You for any advice Roberta, CG for Clyde ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn